Prof. Dr. Claus Jacob Research Group
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[1] M. Sarfraz, M. J. Nasim, C. Jacob, M. C.H. Gruhlke. Yeast Chemogenetic Screening as a Tool to Unravel the Antifungal Mode of Action of Two Selected Selenocyanates. Appl. Sci.-Basel (2019)
[2] N. Sahakyan, M. Petrosyan, I. Koss-Mikołajczyk, A. Bartoszek, T. G. Sad, M. J. Nasim, M. Vanidze, A. Kalandia, C. Jacob, A. Trchounian. The Caucasian flora: a still-to-be-discovered rich source of antioxidants. Free Rad Res. (2019)
[3] M. J. Nasim, K. Witek, A. Kincses, A. Y. Abdin, E. Żesławska, M. A. Marć, M. Gajdács, G. Spengler, W. Nitek, G. Latacz, E. Karczewska, K. Kieć-Kononowicz, J. Handzlik, C. Jacob. Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria. New J Chem, 43, 6021-6031. (2019)
[4] S.L. Wadgaonkar, Y.V. Nancharaiah, C. Jacob, G. Esposito, P.N.L. Lens. Microbial transformation of Se oxyanions in cultures of Delftia lacustris grown under aerobic conditions. J Microbiol, 57(5):362-371..(2019)
[5] C. Jacob, M. Rittman, F. Vazquez, A:Y. Abdin. Evolution of Sci's Community-Driven Post-Publication Peer-Review. Sci, 1, 16. (2019)
[6] A. Kharma, M. Grman, A. Misak, E. Domínguez-Álvarez, M.J. Nasim, K. Ondrias, M. Chovanec, C. Jacob. Inorganic Polysulfides and Related Reactive Sulfur–Selenium Species from the Perspective of Chemistry. Molecules, 24, 1359. (2019)
[7] R. Alhasan, M. J. Nasim, C. Jacob, C. Gaucher. Selenoneine: a Unique Reactive Selenium Species From the Blood of Tuna With Implications for Human Diseases. Curr Pharmacol Rep 5: 163. (2019)
[8] K. Khairan, L.A. Ba, T. Burkholz,M.Leroch, M.Hahn, T. Schwab, M.Klotz, K-H. Schaefer, C. Jacob. Electrochemical Potential-Biological Activity Relationships of Cyclic Sulfur-Containing Molecules Against Steinernema feltiae, Botrytis cinerea, and Neuro 2a Cell Line. Curr Pharmacol Rep 5: 174. (2019)
[9] C.Aloke, I.I.Ezeigbo, I.C. Ohanenye, C.C.Udenigwe, C. Jacob, C.E.C.C. Ejike. A Small Green Red-Ox Carries a Bright Medical Future for Sub-Saharan Africa. Curr Pharmacol Rep 5: 245 (2019)
[10] Nasim, M.J.; Alhasan, R.; Abdin, A.Y.; Alnahas, F.; Jacob, C. Inspired by Nature: Redox Modulators and Natural Nanoparticles. Proceedings, 11, 24 (2019)
[11] N.K.Tittikpina, L. P.Sandjo, F. Nana, V. Vaillant, S. Fontanaya, S. Philippot, Y. M.Dioph, K. Batawila, K. Akpagana, G. Kirsch, R. E. Duval, C. Jacob, P. Chaimbault. Investigation of the antifungal activity of Pterocarpus erinaceus led to the identification of two new diarylpropanoids from its roots. Phytochem Lett 32, 110-114. (2019)
[12] E.N. da Silva Júnior, G.A.M. Jardim, C. Jacob, U. Dhawa, L. Ackermann, S.L. de Castro. Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones. Eur J Med Chem ;179:863-915. doi: 10.1016/j.ejmech.2019.06.056 (2019)
[13] A.Y. Abdin, D. Auker-Howlett, J. Landes, G. Mulla, C. Jacob, B. Osimani. Reviewing the mechanistic evidence assessors E-Synthesis and EBM+: A case study of amoxicillin and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Curr Pharm Des doi: 10.2174/1381612825666190628160603 (2019)
[14] A. Kharma, A. Misak, M. Grman, V. Brezova, L. Kurakova, P. Baráth, C. Jacob, M. Chovanec, K. Ondrias, E. Domínguez-Álvarez. Release of reactive selenium species from phthalic selenoanhydride in the presence of hydrogen sulfide and glutathione with implications for cancer research. New J Chem 43, 11771-117832019 (2019)
[15] D. Kołodziejski, I. Koss-Mikołajczyk, A.Y. Abdin, C. Jacob, A. Bartoszek. Chemical aspects of biological activity of isothiocyanates and indoles, the products of glucosinolate decomposition. Curr Pharm Des. doi: 10.2174/1381612825666190701151644 (2019)
[16] R. Alhasan, A. Kharma, P. Leroy, C. Jacob, C. Gaucher. Selenium donors at the junction of inflammatory diseases. Curr Pharm Des. doi: 10.2174/1381612825666190701153903 (2019)
[17] N.E.B. Saidu, N. Kavian, K. Leroy, C. Jacob , C. Nicco, F. Batteux, J. Alexandre. Dimethyl fumarate, a two-edged drug: Current status and future directions. Med Res Rev, doi: 10.1002/med.21567. (2019)
[18] N. Hamdi, Souad Chaouch, Ivan da Silva, Mohamed Ezahri, Mohammed Lachkar, Rama Alhasan, Ahmad Yaman Abdin, Claus Jacob and Brahim El Bali Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (C4N2H14)Co(H2PO3)4·2H2O. Sci, 1(1), 13; (2019)
[19] J. A. Tur, C. Jacob, P. Chaimbault, M. Tadayyon, E. Richling, N. Hermans, C. N. dos Santos, M. Diederich, L. Giblin, M. Elhabiri, C. Gaucher, P. Andreoletti, A. Fernandes, M. Davies, A. Bartoszek, M. Cherkaoui-Malki. Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112). Free Rad Res, doi.org/10.1080/10715762. 2019.1572890 (2019)
[20] G. G. Dias, T. A. do Nascimento, A. K. A. de Almeida, A. C. S. Bombaça, R. F. S. Menna‐Barreto, C. Jacob, S. Warratz, E.N. da Silva Júnior, L. Ackermann, Ruthenium(II)-Catalyzed C-H Alkenylation of Quinones: Diversity-Oriented Strategy for Trypanocidal Compounds. Eur J Org Chem. doi.org/10.1002/ejoc.201900004 (2019)
[21] R. Alhasan, A. Kharma, M. J. Nasim, A. Y. Abdin, J. Bonetti, P. Giummelli, C. E.C.C. Ejike, P. Leroy, C. Gaucher, C. Jacob, Flush with a flash: Natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite. Med. Chem. commun., 9(12), 1994-1999, (2018)
[22] G.G. Dias, T. Rogge , R. Kuniyil, C. Jacob, R.F.S. Menna-Barreto, E.N. da Silva Júnior, L. Ackermann, Ruthenium-catalyzed C-H oxygenation of quinones by weak O-coordination for potent trypanocidal agents. Chem Commun, 13;54(91):12840-12843. (2018)
[23] R. Kurczab, W. Ali, D. Łażewska, M. Kotańska, M. Jastrzębska-Więsek, G. Satała, M. Więcek, A. Lubelska, G. Latacz, A. Partyka, M. Starek, M. Dąbrowska, A. Wesołowska, C. Jacob, KI. Kieć-Kononowicz , J .Handzlik, Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT₆ Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo. Molecules. 23(10), 2529 (2018).
[24] M. J. Nasim, P. Denezhkin, M. Sarfraz, R. Leontiev, Y. Ney, A. Kharma, S. Griffin, M. I. Masood, C. Jacob, The Small Matter of a Red Ox, a Particularly Sensitive Pink Cat, and the Quest for the Yellow Stone of Wisdom. Curr. Pharmacol. Rep. 4:380–396 (2018)
[25] K. Khairan, J. Vincent, C. Jacob, Study Cytotoxicity of Haarlem Oil by Crystal Violet Staining Assay. Res. J. Chem. Environ. 22, 198-202, (2018)
[26] S. Shaaban, D. Vervandier-Fasseur,P. Andreoletti, A. Zarrouk, P. Richard, A. Negm, G. Manolikakes, ,C. Jacob, M. Cherkaoui-Malki, Cytoprotective and antioxidant properties of organic selenides for the myelin-forming cells, oligodendrocytes. Bioorg. Chem.80, 43-56 (2018)
[27] Y. Ney, M. J. Nasim, A. Kharma, L. A. Youssef, C. Jacob, Small Molecule Catalysts with Therapeutic Potential Molecules; 23(4), 765 (2018)
[28] R. Leontiev, N. Hohaus, C. Jacob, M. C. H. Gruhlke, A. J. Slusarenko, A Comparison of the Antibacterial and Antifungal Activities of Thiosulfinate Analogues of Allicin. Scientific Reports; 8, 6763 (2018)
[29] S. Griffin, M. Sarfraz, S. F. Hartmann, S. R. Pinnapireddy, M. J. Nasim, U. Bakowsky, M. C. M. Keck, C. Jacob, Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms. Antioxidants;7(2), 23. (2018)
[30] M. Sarfraz, S. Griffin, T. G. Sad, R. Alhasan, M. J. Nasim, M. I. Masood, K. H. Schäfer, C. E.C.C. Ejike, C. M. Keck ,C. Jacob, A. P. Ebokaiwe, Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Into antimicrobial Materials. Antioxidants; 7(4), 60 (2018)
[31] S. Griffin, M. Sarfraz, V. Farida, M: J. Nasim, A. P. Ebokaiwe,C. M. Keck, C. Jacob, No time to waste organic waste: Nanosizing converts remains of food processing into refined materials, J Environ Manage, 210, 114-121 (2018)
[32] G. A .M. Jardim, E. H. G. da Cruz, W. O. Valença, D. J. B. Lima, B. C. Cavalcanti, C. Pessoa, J. Rafique, A. L. Braga, C. Jacob, E. N. da Silva Júnior. Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions. Molecules. ;23(1). (2018)
[33] S. Griffin, M. I. Masood , M. J. Nasim, M. Sarfraz, A. P. Ebokaiwe, K-H. Schäfer, C. M. Keck, C. Jacob, Natural Nanoparticles: A Particular Matter Inspired by Nature. Antioxidants.;7(1). (2018)
[34] M. J. Nasim, W. Ali, ,E. Dominguez-Álvarez, E. N. da Silva Júnior, R. S. Z. Saleem, C. Jacob. Reactive Selenium Species: Redox Modulation, Antioxidant, Antimicrobial and Anticancer Activities. In book: Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments. Royal Society of Chemistry, 277-302 (2018)
[35] N.K. Tittikpina, F. Nana, S. Fontanay, S. Philippot, K. Batawila, K. Akpagana, G. Kirsch, P. Chaimbault, C. Jacob, R.E. Duval, Antibacterial activity and cytotoxicity of Pterocarpus erinaceus Poir extracts, fractions and isolated compounds. J Ethnopharmacol.212, 200-207. (2018)
[36] K. Witek, M. J. Nasim, M. Bischoff, R. Gaupp, P. Arsenyan, J. Vasiljeva, M. A. Marć , A. Olejarz, G. Latacz, K. Kieć-Kononowicz, J. Handzlik, C. Jacob, Selenazolinium Salts as "Small Molecule Catalysts" with High Potency against ESKAPE Bacterial Pathogens. Molecules.;22(12) (2017)
[37] E. Y. Efe A. Mazumder, J. Lee, A. Gaigneaux F. Radogna, M. J. Nasim, Christo Christov , Claus Jacob, K. Kim, M. Dicato, P. Chaimbault, C. Cerella, M. Diederich. Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal cancer. Cancer Letters, 410, 139-157 (2017).
[38] N. Koko Tittikpina, F. Nana, S. Fontanay, S. Philippot, K. Batawila, K. Akpagana, G. Kirsch, P. Chaimbault, C. Jacob, R. Emmanuel Duval, Antibacterial activity and cytotoxicity of Pterocarpus erinaceus Poir extracts, fractions and isolated compounds, Journal of Ethnopharmacology, (2017).
[39] N. K. Tittikpina, W. Atakpama, H. Pereki, M. J. Nasim, W. Ali, S. Fontanay, F. Nana, C. E. C. C. Ejike, G. Kirsch, R. E. Duval, P. Chaimbault, S. D. Karou, K. Batawila, K. Akpagana, C. Jacob ‘Capiture’ plants with interesting biological activities: a case to go. Open chemistry, 15, 1-11 (2017).
[40] E. Jabeen, N. K. Janjua, S. Ahmed, E. Domínguez-Álvarez, C. Jacob. A selective and sensitive monitoring of the OH radical using flavonoid-modified electrodes. Electrochimica Acta, 258 (20) , 228-235 ( 2017).
[41] F. Albrecht, R. Leontiev, C. Jacob, A.J. Slusarenko, An Optimized Facile Procedure to Synthesize and Purify Allicin, Molecules, 22, (2017).
[42] E.C. Estevam, S. Griffin, M.J. Nasim, P. Denezhkin, R. Schneider, R. Lilischkis, E. Dominguez-Alvarez, K. Witek, G. Latacz, C. Keck, K.H. Schafer, K. Kie-Kononowicz, J. Handzlik, C. Jacob, Natural selenium particles from Staphylococcus carnosus: Hazards or particles with particular promise?, Journal of Hazardous Materials, 324, 22-30, (2017).
[43] W.O. Valenca, T.V. Baiju, F.G. Brito, M.H. Araujo, C. Pessoa, B.C. Cavalcanti, C.A. de Simone, C. Jacob, I.N.N. Namboothiri, E.N. da Silva, Synthesis of Quinone-Based N-Sulfonyl-1,2,3-triazoles: Chemical Reactivity of Rh(II) Azavinyl Carbenes and Antitumor Activity, Chemistry select, 2 4301-4308, (2017).
[44] S. Griffin, R. Alkhayer, S. Mirzoyan, A. Turabyan, P. Zucca, M. Sarfraz, M. J. Nasim, A. Trchounian, A. Rescigno, C. M. Keck, C. Jacob, Nanosizing Cynomorium: Thumbs up for Potential Antifungal Applications. Inventions, 2(3), 24 1-10, (2017).
[45] G.I. Giles, M.J. Nasim, W. Ali, C. Jacob, The Reactive Sulfur Species Concept: 15 Years On. Antioxidants, 6(2):38, 1-29, (2017).
[46] J. Rendeková, D. Vlasáková, P. Arsenyan, J. Vasiljeva, M. J. Nasim, K. Witek, E. Domínguez-Álvarez, E. Żesławska, D. Mániková, W. Tejchman, R. S. Z. Saleem, K. Rory, J. Handzlik, M. Chovanec, The Selenium-Nitrogen Bond as Basis for Reactive Selenium Species with Pronounced Antimicrobial Activity, Current Organic Synthesis, 14, (2017).
[47] M. Grman, M. J. Nasim, R. Leontiev, A. Misak, V. Jakusova, K. Ondrias, C. Jacob, Inorganic Reactive Sulfur-Nitrogen Species: Intricate Release Mechanisms or Cacophony in Yellow, Blue and Red?, Antioxidants, 6(1), (2017).
[48] L. Faulstich, S. Griffin, M.J. Nasim, M.I. Masood, W. Ali, S. Alhamound, Y. Omran, H. Kim, A. Kharma, K.H. Schaefer, R. Lilischkis, M. Montenarh, C. Keck, C. Jacob, Nature's Hat-trick: Can we use sulfur springs as ecological source for materials with agricultural and medical applications?, International . Biodeterioration and Biodegradation, 119, 678-686, (2017).
[49] C. Zwergel, B. Czepukojc, E. Evain-Bana, Z. Xu, G. Stazi, M. Mori, A. Patsilinakos, A. Mai, B. Botta, R. Ragno, D. Bagrel, G. Kirsch , P. Meiser, C. Jacob, M. Montenarh, S. Valente, Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells, European Journal of Medicinal. Chemistry, 134, 316-333, ( 2017).
[50] S. Griffin, N. K. Tittikpina, A. Al-marby, R. Alkhayer, P. Denezhkin, K. Witek K. A. Gbogbo, K. Batawila, R. E. Duval, M. J. Nasim, N. A. Awadh-Ali, G. Kirsch, P. Chaimbault, K-H. Schäfer, C. M. Keck, J. Handzlik, C. Jacob, Turning Waste into Value: Nanosized Natural Plant Materials of Solanum incanum L. and Pterocarpus erinaceus Poir with Promising Antimicrobial Activities, Pharmaceutics, 8(2): 11, (2016).
[51] E. C. Estevam, L. Faulstich, S. Griffin, T. Burkholz, C. Jacob. Polysulfides in Biology: From Intricate Chemistry to an Astonishing Yet Hidden Biological Activity. Current Organic Chemistry, 20(2) : 211 – 217, (2016).
[52] E. Domínguez-Álvarez, M. Gajdács, G. Spengler, J.A. Palop, M.A. Marć, K. Kieć-Kononowicz, L. Amaral, J. Molnár, C. Jacob, J. Handzlik, C. Sanmartín, Identification of selenocompounds with promising properties to reverse cancer multidrug resistance, Bioorganic and Medicinal Chemistry Letters 26(12):2821-4, (2016).
[53] O. Talhi, L. Brodziak-Jarosz, J. Panning, B. Orlikova, C. Zwergel, T. Tzanova, S. Philippot, D.C. G. A. Pinto, F. A. A. Paz, C. Gerhäuser, T. P. Dick, C. Jacob, M. Diederich, D. Bagrel, G. Kirsch, A. M. S. Silva, One-Pot Synthesis of Benzopyran-4-ones with Cancer Preventive and Therapeutic Potential. European Journal of Organic Chemistry, 5, 965–975, (2016).
[54] A. Al-Marby, C.E.C.C. Ejike, M.J. Nasim, N.A. Awadh-Ali, R.A. Al-badani, G.M.A. Alghamdi , C. Jacob, Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula, Journal of Intercultural Ethnopharmacology, 5(1): 1-6, (2016).
[55] N.K. Tittikpina, C.E.C.C. Ejike, E. Castelluci Estevam, M.J. Nasim, S. Griffin, P. Chaimbault, G. Kirsch, W. Atakpama, K. Batawila, C. Jacob, Togo to go: Products and compounds derived from local plants for the treatment of diseases endemic in sub-Saharan Africa, African Journal of Traditional Complementary and Alternative Medicine, 13(1):85-94, (2016).
[56] E. Castellucci Estevam, S. Griffin, M.J. Nasim, D. Zieliński, J. Aszyk, M. Osowicka, N. Dawidowska, R. Idroes, A. Bartoszek, C. Jacob, Inspired by Nature: The Use of Plant-derived Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ, Natural Product Communication, 10(10), 1733-1738, (2015).
[57] D. Rezk Allah, L. Schwind, I. Abu Asali, J. Nasim, C. Jacob, C. Götz, M. Montenarh, A scent of therapy: Synthetic polysulfanes with improved physico-chemical properties induce apoptosis in human cancer cells, International Journal of Oncology, 47 (3), 991-1000, (2015).
[58] C. Zwergel, S. Valente, C. Jacob, A. Mai, Emerging approaches for histone deacetylase inhibitor drug discovery, Expert Opinion on Drug Discovery, 10 (6), (2015).
[59] M. Grman, E. Ondriasova, J. Nasim, C. Jacob, K. Ondrias, Decomposition of S-nitrosoglutathione by interaction with organic polysulfides and reduced thiols, Nitric Oxide, 47, (2015).
[60] E. Castellucci Estevam , K. Witek , L. Faulstich , M.J. Nasim , G. Latacz , E. Domínguez-Álvarez , K. Kieć-Kononowicz , M. Demasi , J. Handzlik, C. Jacob, Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design, Molecules, 20, 13894-13912, (2015).
[61] A.K.K. Bhasin, C. Jacob, F. Sasse, K. Karaghiosoff , K.K. Bhasin, S.K. Mehta, Alka Sharma, Rishu, Design, synthesis and characterization of picoline based organoselenium compounds, 1,2-bis(pyridine-2/3/4-yl)methyl diselanes: X-ray crystal structure of 1,2-bis(pyridine-3-y1) methyldiselane, Journal of Organometallic Chemistry, 785, 19-25, (2015).
[62] E. Domínguez, D. Plano, M. Font, A. Calvo, C. Prior, C. Jacob, J.A. Palop, C. Sanmartín, Synthesis and antiproliferative activity of novel selenoester derivative, European Journal of Medicinal Chemistry, 73, 153-166 (2014).
[63] O. Talhi, M. Schnekenburger, J. Panning, D.G.C. Pinto, J.A. Fernandes, F.A. Almeida Paz, C. Jacob, M. Diederich, A.M.S. Silva, Bis(4-hydroxy-2H-chromen-2-one): Synthesis and effects on leukemic cell lines proliferation and NF-jB regulation, Bioorganic & Medicinal Chemistry, 22, 3008–3015 (2014)
[64] A. Nucci, F.M. Merlo, M. De Nisco, S. Pedatella, F. Rossi, C. Jacob, R. Caputo, A. Mastino, Se-(2-aminoalkyl)selenocysteines as biochemical redox agents. A tool to contrast cell injury induced by aflatoxin B1 in HepG2 cells, Amino Acids, 46(2), 459-470 (2014).
[65] B. Czepukojc, A.K. Baltes, M. Kelkel, C. Cerella, U.M. Viswanathan, F. Salm, T. Burkholz, C. Schneider, M. Montenarh, M. Diederich, C. Jacob, Towards pharmaceutically useful, redox-modulating polysulfanes based on naturally occurring garlic compounds, Food and Chemical Toxicology, 64, 249–257 (2014).
[66] P. Du, U.M. Viswanathan, K. Khairan, T. Buric, N.E.B. Saidu, Z. Xu, B. Hanf, I. Bazukyan, A. Trchounian, F. Hannemann, I. Bernhardt, T. Burkholz, B. Diesel, A.K. Kiemer, K.-H. Schaefer, M. Montenarh, G. Kirsch, C. Jacob, Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbes, Med.Chem.Comm., 5, 25-31 (2014).
[67] P. Du, U.M. Viswanathan, Z. Xu, H. Ebrahimnejad, B. Hanf, T. Burkholz, M. Schneider, I. Bernhardt, G. Kirsch, M. Montenarh, C. Jacob, Synthesis and biological activity of amphiphilic seleninic acid derivatives with considerable activity against membranes, cancer cells and certain pathogenic microbes, Journal of Hazardous Materials, 269, 74–82 (2014).
[68] P. Du, N.E:B. Saidu, J. Intemann, C. Jacob, M. Montenarh, A new tellurium-containing amphiphilic molecule induces apoptosis in HCT116 colon cancer cells, Biochim Biophys Acta, 1840(6), 1808-16 (2014).
[69] T. Burkholz, M. Egert, C. Jacob, Elektrochemische Dekontamination von leitenden Oberflächen: Von grundlegenden Ideen zu neuen Ansätzen, WOMAG Oberflächen, Ausgabe 6/2014.
[70] O. Talhi, M. Schnekenburger, J. Panning, D.G.C. Pinto, J.A. Fernandes, F.A. Almeida Paz, C. Jacob, M. Diederich, A.M.S. Silva, Bis(4-hydroxy-2H-chromen-2-one): Synthesis and effects on leukemic cell lines proliferation and NF-κB regulation, Bioorganic & Medicinal Chemistry, 22 (11), 3008–3015 (2014).
[71] V. Jamier, W. Marut, S. Valente, C. Chéreau, S. Chouzenoux, C. Nicco, H. Lemaréchal, B. Weill, G. Kirsch, C. Jacob, F. Batteux, Chalcone-Coumarin Derivatives as Potential Anti-Cancer Drugs: An in vitro and in vivo Investigation, Anti-Cancer Agents in Medicinal Chemistry, 14(7), 963-74 (2014).
[72] D. Mániková, L.M. Letavayová, D. Vlasáková, P. Košík, E. Castellucci Estevam, M.J. Nasim, M. Gruhlke, A. Slusarenko, T. Burkholz, C. Jacob, M. Chovanec, Intracellular Diagnostics: Hunting for the Mode of Action of Redox-Modulating Selenium Compounds in Selected Model Systems, Molecules, 19(8), 12258-12279 (2014).
[73] C. Jacob, Special Issue: Redox Active Natural Products and Their Interaction with Cellular Signalling Pathways, Molecules, 19, 19588-19593 (2014).
[74] L.-O. Klotz, X. Hou, C. Jacob, 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling, Molecules, 19, 14902-14918 (2014).
[75] S. Shaaban, F. Sasse, T. Burkholz, C. Jacob, Sulfur, selenium and tellurium pseudopeptides: Synthesis and biological evaluation, Bioorganic & Medicinal Chemistry, 22, 3610–3619 (2014).
[76] C. Jacob, G. Kirsch, A. Slusarenko, P.G. Winyard, T. Burkholz (eds.), Recent Advances in Redox Active Plant and Microbial Products: From basic chemistry to widespread applications in Medicine and Agriculture, Springer Science, ISBN: 978-9401789523 (2015).
[77] T. Burkholz, C. Jacob, A word on redox activity, in: C. Jacob, G. Kirsch, A. Slusarenko, P.G. Winyard, T. Burkholz (eds.), Recent Advances in Redox Active Plant and Microbial Products: From basic chemistry to widespread applications in Medicine and Agriculture, Springer Science (2015).
[78] H. Ebrahimnejad, T. Burkholz, C. Jacob, Treasures along the oligomeric road from flavonoids to polyphenols and tannins, in: C. Jacob, G. Kirsch, A. Slusarenko, P.G. Winyard, T. Burkholz (eds.), Recent Advances in Redox Active Plant and Microbial Products: From basic chemistry to widespread applications in Medicine and Agriculture, Springer Science (2015).
[79] L.S. Sargsyan, K.R. Grigoryan, T. Burkholz, S.A. Markarian, C. Jacob, Fluorescence characterisation of human haemoglobin binding binding with tannic acid, Chemical Journal of Armenia, 67(2-3), 181-187 (2014).
[80] C. Jacob, L. Faulstich, M.J Nasim, T. Burkholz, Von der Natur inspiriert: Redox-aktive Nahrungsbestandteile (Metabolite) mit vielseitigen Anwendungen in der Medizin und Landwirtschaft, Magazin Forschung, Ausgabe 2/2014 (2014)
[81] W. Marut, V. Jamier, N. Kavian, A. Servettaz, P. Winyard, P. Eggleton, A. Anwar, C. Nicco, C. Jacob, C. Chéreau, B. Weill, F. Batteux, The Natural Organosulfur compound Dipropyltetrasulfide Prevents HOCl-Induced Systemic Sclerosis in the Mouse, Arthritis Research & Therapy, 15. 167 (2013).
[82] L. Dejon, H. Mohammed, P. Du, C. Jacob, A. Speicher, Synthesis of tetrahydrochromenoindole derivatives from Robinia pseudoacacia, Med. Chem. Commun., (2013), DOI: 10.1039/C3MD00213F.
[83] B. Czepukojc, M. Leroch, F. Salm, U.M. Viswanathan, T. Burkholz, M. Hahn, C. Jacob, Antifungal activity of tetrasulfanes against Botrytis cinerea, Natural Product Communications, 8(11), 1599-1603 (2013).
[84] N.E.B. Saidu, I.A. Asali, B. Czepukojc, B. Seitz, C. Jacob, M. Montenarh, Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells, Biochimica et Biophysica Acta, 1830(11), 5267-5276 (2013).
[85] Y. Yu, B. Czepukojc, C. Jacob, Y. Jiang, M. Zeller, C. Brückner, J.-L. Zhang, Porphothionolactones: Synthesis, structure, physical, and chemical properties of a chemodosimeter for hypochlorite, Organic & Biomolecular Chemistry, 11(28), 4613-21 (2013).
[86] T. Burkholz, C. Jacob, Tellurium in Nature, in: R.H. Kretsinger, V.N. Uversky, E.A. Permyakov, (eds.), Encyclopaedia of Metalloproteins, 2163-2174 (2013).
[87] M. Grman, A. Misak, C. Jacob, Z. Tomaskova, A. Bertova, T. Burkholz, P. Docolomansky, L. Habala, K. Ondrias, Low molecular thiols, pH and O2 modulate H2S induced •NO release from S-nitrosoglutathione, General Physiology and Biophysics, 32, 429–441 (2013).
[88] B. Czepukojc, U.M. Viswanathan, A. Raza, S. Ali, T. Burkholz, C Jacob, Tetrasulfanes as Selective Modulators of the Cellular Thiolstat, Phosphorus, Sulfur, and Silicon and the related elements, 188(4), 446-453 (2013).
[89] S. Valente, Z. Xu, E. Bana, C. Zwergel, A. Mai, C. Jacob, P. Meiser, D. Bagrel, A.M.S. Silva, G. Kirsch, Reactivity of 4-Vinyl-2H-1-benzopyran-2-ones in Diels–Alder Cycloaddition Reactions: Access to Coumarin-Based Polycycles with Cdc25 Phosphatase-Inhibiting Activity, European Journal of Organic Chemistry, DOI: 10.1002/ejoc.201201736 (2013).
[90] U.M. Viswanathan, T. Burkholz and C. Jacob, Electrochemistry at the edge of reason: Chalcogen-based redox systems in biochemistry and drug design, Zeitschrift für Physikalische Chemie, 227(5), 691-706 (2013).
[91] E. Domínguez Álvarez, U.M. Viswanathan, T. Burkholz, K. Khairan, C. Jacob, Bio-Electrochemistry and Chalcogens, Chapter 7, in M. Schlesinger (ed.), Applications of Electrochemistry in Medicine, Modern Aspects of Electrochemistry, 56, 249-282 (2013).
[92] N.E.B. Saidu, R. Touma, I.A. Asali, C. Jacob, M. Montenarh, Diallyl tetrasulfane activates both the eIF2α and Nrf2/HO-1 pathways, Biochimica et Biophysica Acta, 1830, 2214–2225 (2013).
[93] P. Du, U.M. Viswanathan, Z. Xu, H. Ebrahimnejad, B. Hanf, T. Burkholz, M. Schneider, I. Bernhardt, G. Kirsch, M. Montenarh, C. Jacob, Emerging Biological Applications of Chalcogens: Amphiphilic Selenic Acids with Multiple Impact on Living Cells. in E.R. Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Proceedings of the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 59-68 (2013).
[94] A.K.K. Bhasin, E. Arora, B. Hinkelmann, F. Sasse, A. Raja, Y. Muthukumar, K.K. Bhasin, S.K. Mehta, T. Burkholz, C. Jacob, Synthesis, Structural Elucidation and Anticarcinogenic Potential of a New Selenium-incorporated Tricyclic Quinoline. in E.R. Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Proceedings of the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 3-10 (2013).
[95] C. Jacob, T. Burkholz, Emerging biological applications of chalcogens: From the trivial to the more exotic. in E.R. Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Abstract book from the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 37-38 (2013).
[96] A.K.K. Bhasin, F. Sasse, C. Jacob, E. Arora, S.K. Mehta, K.K. Bhasin, Design, synthesis and characterisation of novel quinolone-based selenium compounds: X-ray structure of 3H-[1,2]diselenolo[3,4b]quinoline. in E.R. Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Abstract book from the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 37-38 (2013).
[97] K.K. Bhasin, Ekta Arora, Alka S. Grover, Jyoti, H. Singh, S.K. Mehta, A.K.K. Bhasin, C. Jacob, Synthesis and characterization of new 2-pyrimidyl chalcogen (S, Se, Te) compounds: X-ray crystal structure of bis(4,6-dimethyl-2-pyrimidyl)diselenide and 4,6-dimethyl-2-(phenylselanyl)pyrimidine, Journal of Organometallic Chemistry, 732, 137-141 (2013).
[98] M. Doering, B. Diesel, M.C.H. Gruhlke, U.M. Viswanathan, T. Burkholz, A. Slusarenko, A.K. Kiemer and C. Jacob, Selenium- and Tellurium-Containing Redox Modulators with Distinct Activity against Macrophages: Possible Implications for the Treatment of Inflammatory Diseases, Tetrahedron, 68, 10577-10585 (2012).
[99] S. Shaaban, R. Diestel, B. Hinkelmann, Y. Muthukumar, R.P. Verma, F. Sasse, C. Jacob, Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents, European Journal of Medicinal Chemistry, 58, 192-205 (2012).
[100] T. Schneider, Y. Muthukumar, B. Hinkelmann, R. Franke, M. Döring, C. Jacob, F. Sasse, Deciphering intracellular targets of organochalcogen based redox catalysts, Med. Chem. Commun., 3, 784 (2012).
[101] B. Czepukojc, T. Schneider, T. Burkholz, V. Jamier, C. Jacob, Natural Sulfur Products as Redox Modulators and Selective Inducers of Cell Death, in M. Diederich, K. Noworyta (eds.), Natural compounds as inducers of cell death: 1, Springer Science, 293-327 (2012).
[102] M. Kelkel, C. Cerella, F. Mack, T. Schneider, C. Jacob, M. Schumacher, M. Dicato, M. Diederich, ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis, Carcinogenesis, 33(11), 2162–2171 (2012).
[103] W. Marut, N. Kavian, A. Servettaz, C. Nicco, L.A. Ba, M. Doering, C. Chereau, C. Jacob, B. Weill, F. Batteux, The Organotelluride Catalyst (PHTE)(2)NQ Prevents HOCl-Induced Systemic Sclerosis in Mouse, Journal of Investigative Dermatology, 132, 1125-1132 (2012).
[104] L.A. Ba, T. Burkholz, T. Schneider, C. Jacob, The Role of Cysteine in Amino Acids, Peptides and Proteins in Organic Chemistry, in A.B. Hughes (ed.), Amino Acids, Peptides and Proteins in Organic Chemistry: Analysis and Function of Amino Acids and Peptides, 5, Wiley-VCH (2012).
[105] C. Jacob, E. Battaglia, T. Burkholz, D. Peng, D. Bagrel, M. Montenarh, Control of oxidative posttranslational cysteine modifications: from intricate chemistry to widespread biological and medical applications, Chemical Research in Toxicology, 25, 588-604 (2012).
[106] Z. Xu, P. Du, P. Meiser and C. Jacob, Proanthocyanidins: Oligomeric Structures with Unique Biochemical Properties and Great Therapeutic Promise, Natural Product Communications, 7(3), 381-388 (2012).
[107] N. Arshad, N.K. Janjua, A.Y. Khan, A. Yaqub, T. Burkholz, C. Jacob, Natural Flavonoids Interact with Dinitrobenzene System in Aprotic Media: An Electrochemical Probing, Natural Product Communications, 7(3), 311-315 (2012).
[108] P.K. Agrawal, T. Burkholz and C. Jacob, Revisit to 25R/25S Stereochemical Analysis of Spirostane-type Steroidal Sapogenins and Steroidal Saponins via 1H NMR Chemical Shift Data, Natural Product Communications, 7(6), 709-711 (2012).
[109] C. Jacob, Redox signalling via the cellular thiolstat, Biochemical Society Transactions, 39(5):1247-53 (2011).
[110] R. Coriat, W. Marut, M. Leconte, L.A. Ba, A. Vienne, C. Chéreau, J. Alexandre, B. Weill, M. Doering, C. Jacob, C. Nicco, F. Batteux, The organotelluride catalyst LAB027 prevents colon cancer growth in the mice, Cell Death and Disease, 2, 191 (2011).
[111] C. Jacob, V. Jamier and L.A. Ba, Redox Active Secondary Metabolites, Current Opinion in Chemical Biology, 15, 149-155 (2011).
[112] N. Lilienthal, C. Prinz, A.A. Peer-Zada, M. Doering, L.A. Ba, M. Hallek, C. Jacob, M. Herling, Targeting the disturbed redox equilibrium in chronic lymphocytic leukemia by novel reactive oxygen species-catalytic ‘sensor/effector’ compounds, Leukemia & Lymphoma, 52(7), 1407–1411 (2011)
[113] H.A. Mohammed, L.A. Ba, T. Burkholz, E. Schumann, B. Diesel, J. Zapp, A.K. Kiemer, C. Ries, R.W. Hartmann, M. Hosny and C. Jacob, Facile Synthesis of Chrysin-derivatives with Promising Activities as Aromatase Inhibitors, Natural Product Communications, 6(1), 31-34 (2011).
[114] E. Viry, A.Anwar, G. Kirsch, C.Jacob, M. Diederich, D. Bagrel, Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases, International Journal of Oncology, 38(4), 1103-1111 (2011).
[115] T. Schneider, A. Baldauf, L.A. Ba, V. Jamier, K. Yusuf, M.-B. Sarakbi, N. Reum, M. Schneider, A. Röseler, K. Becker, T. Burkholz, P. G. Winyard, M. Kelkel, M. Diederich and C. Jacob, Selective antimicrobial activity associated with sulfur nanoparticles, Journal of Biomedical Nanotechnology, 7, 395-405 (2011).
[116] T. Schneider, T., L.A. Ba, K. Khairan, C. Zwergel, N.D. Bach, I. Bernhardt, W. Brandt, L. Wessjohann, M. Diederich, C. Jacob, Interactions of polysulfanes with components of red blood cells, Med. Chem. Commun., 2, 196-200 (2011).
[117] C. Jacob, L.A. Ba, Open season for hunting and trapping posttranslational cysteine modifications in proteins and enzymes, ChemBioChem, 12, 841-844 (2011).
[118] C. Cerella, M. Dicato, C. Jacob, M. Diederich, Chemical Properties and Mechanisms Determining the Anti-Cancer Action of Garlic-Derived Organic Sulfur Compounds, Anti-Cancer Agents in Medicinal Chemistry, 5, 267-271 (2011).
[119] N.K. Janjua, A. Shaheen, A. Yaqub, F. Perveen, S. Sabahat, M. Mumtaz, C. Jacob, L.A. Ba, H.A. Mohammed, Flavonoid–DNA binding studies and thermodynamic parameters, Spectrochimica Acta Part A, 79, 1600–1604 (2011).
[120] M.C.H. Gruhlke, D. Portz, M. Stitz, A. Anwar, T. Schneider, C. Jacob, N.L. Schlaich, A.J. Slusarenko, Allicin disrupts the cell's electrochemical potential and induces apoptosis in yeast, Free Radical Biology and Medicine, 49, 1916-1924 (2010).
[121] M. Kelkel, C. Jacob, M. Dicato and M. Diederich, Potential of the dietary antioxidants resveratrol and curcumin in prevention and treatment of hematologic molecules, Molecules, 15, 7035-7074 (2010).
[122] M. Doering, L.A. Ba, N. Lilienthal, C. Nicco, C. Scherer, M. Abbas, A.A. Peer Zada, R. Coriat, T. Burkholz, L. Wessjohann, M. Diederich, F. Batteux, M. Herling and C. Jacob, Synthesis and selective anti-cancer activity of novel organotellurium based redox catalysts, Journal of Medicinal Chemistry, 53, 6954-6963 (2010).
[123] V. Jamier, L.A. Ba and C. Jacob, Selenium- and Tellurium-containing Multifunctional Redox Agents, Chemistry - A European Journal, 16, 10920-10928 (2010).
[124] L.A. Ba, V. Jamier, M. Doering and C. Jacob, Tellurium: An element with great potency and potential, Organic & Biomolecular Chemistry, 8, 4203-4216 (2010), Invited Emerging Area manuscript.
[125] C. Busch, C. Jacob, A. Anwar, T. Burkholz, L.A. Ba, C. Cerella, M. Diederich, W. Brandt, L. Wessjohann and M. Montenarh, Diallylpolysulfides induce growth arrest and apoptosis, International Journal of Oncology, 36(3), 743-749 (2010).
[126] C. Scherer, C. Jacob, M. Dicato and M. Diederich, Allylsulfides as bioactive compounds with chemotherapeutic and/or chemopreventive effects, in: I. Rasooli (ed.) Phytochemicals - Bioactivities and Impact on Health, ISBN 978-953-307-424-5, InTech (2010).
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