Prof. Dr. Claus Jacob Research Group

List of Publications

image3

 

If you are interested in a specific publication, please do not hesitate to contact us directly

2019

 

[1]   M. Sarfraz, M. J. Nasim, C. Jacob, M. C.H.  Gruhlke. Yeast Chemogenetic Screening as a Tool to Unravel the  Antifungal Mode of Action of Two Selected Selenocyanates. Appl. Sci.-Basel  (2019) 

[2]   N. Sahakyan, M. Petrosyan, I.  Koss-Mikołajczyk, A. Bartoszek, T. G. Sad, M. J. Nasim, M. Vanidze, A.  Kalandia, C. Jacob, A. Trchounian. The Caucasian flora: a  still-to-be-discovered rich source of antioxidants. Free Rad Res. (2019)

[3]   M. J. Nasim, K. Witek, A. Kincses, A. Y.  Abdin, E. Żesławska, M. A. Marć, M. Gajdács, G. Spengler, W. Nitek, G.  Latacz, E. Karczewska, K. Kieć-Kononowicz, J. Handzlik, C. Jacob.  Pronounced activity of aromatic selenocyanates against multidrug  resistant ESKAPE bacteria. New J Chem, 43, 6021-6031. (2019)

[4]   S.L. Wadgaonkar, Y.V. Nancharaiah, C. Jacob,  G. Esposito, P.N.L. Lens. Microbial transformation of Se oxyanions in  cultures of Delftia lacustris grown under aerobic conditions. J Microbiol, 57(5):362-371..(2019)

[5]   C. Jacob, M. Rittman, F. Vazquez, A:Y.  Abdin. Evolution of Sci's Community-Driven Post-Publication Peer-Review. Sci, 1, 16. (2019)

[6]   A. Kharma, M. Grman, A. Misak, E.  Domínguez-Álvarez, M.J. Nasim, K. Ondrias, M. Chovanec, C. Jacob.  Inorganic Polysulfides and Related Reactive Sulfur–Selenium Species from  the Perspective of Chemistry. Molecules, 24, 1359. (2019)

[7]   R. Alhasan, M. J. Nasim, C. Jacob, C.  Gaucher. Selenoneine: a Unique Reactive Selenium Species From the Blood  of Tuna With Implications for Human Diseases. Curr Pharmacol Rep 5: 163. (2019)

[8]        K. Khairan,  L.A. Ba, T.  Burkholz,M.Leroch, M.Hahn, T. Schwab, M.Klotz, K-H. Schaefer, C. Jacob.  Electrochemical Potential-Biological Activity Relationships of Cyclic  Sulfur-Containing Molecules Against Steinernema feltiae, Botrytis  cinerea, and Neuro 2a Cell Line. Curr Pharmacol Rep 5: 174. (2019)

[9]        C.Aloke, I.I.Ezeigbo, I.C. Ohanenye,  C.C.Udenigwe, C. Jacob, C.E.C.C. Ejike. A Small Green Red-Ox Carries a  Bright Medical Future for Sub-Saharan Africa. Curr Pharmacol Rep 5: 245 (2019)

[10]      Nasim, M.J.; Alhasan, R.; Abdin, A.Y.;  Alnahas, F.; Jacob, C. Inspired by Nature: Redox Modulators and Natural  Nanoparticles. Proceedings, 11, 24 (2019)

[11]      N.K.Tittikpina, L.  P.Sandjo, F. Nana,  V. Vaillant, S. Fontanaya, S. Philippot, Y. M.Dioph, K. Batawila, K.  Akpagana, G. Kirsch, R. E. Duval, C. Jacob, P. Chaimbault. Investigation  of the antifungal activity of Pterocarpus erinaceus led to the  identification of two new diarylpropanoids from its roots. Phytochem Lett 32, 110-114. (2019)

[12]      E.N. da Silva Júnior, G.A.M. Jardim, C.  Jacob, U. Dhawa, L. Ackermann, S.L. de Castro. Synthesis of quinones  with highlighted biological applications: A critical update on the  strategies towards bioactive compounds with emphasis on lapachones. Eur J Med Chem ;179:863-915. doi: 10.1016/j.ejmech.2019.06.056 (2019)

[13]      A.Y. Abdin, D. Auker-Howlett, J. Landes,  G. Mulla, C. Jacob, B. Osimani. Reviewing the mechanistic evidence  assessors E-Synthesis and EBM+: A case study of amoxicillin and Drug  Reaction with Eosinophilia and Systemic Symptoms (DRESS). Curr Pharm Des doi: 10.2174/1381612825666190628160603 (2019) 

[14]      A. Kharma, A. Misak, M. Grman, V.  Brezova, L. Kurakova, P. Baráth,  C. Jacob, M. Chovanec, K. Ondrias,  E.  Domínguez-Álvarez. Release of reactive selenium species from phthalic  selenoanhydride in the presence of hydrogen sulfide and glutathione with  implications for cancer research. New J Chem 43, 11771-117832019 (2019)

[15]      D. Kołodziejski, I. Koss-Mikołajczyk,  A.Y. Abdin, C. Jacob, A. Bartoszek. Chemical aspects of biological  activity of isothiocyanates and indoles, the products of glucosinolate  decomposition. Curr Pharm Des. doi: 10.2174/1381612825666190701151644 (2019) 

[16]      R. Alhasan, A. Kharma, P. Leroy, C. Jacob, C. Gaucher. Selenium donors at the junction of inflammatory diseases. Curr Pharm Des. doi: 10.2174/1381612825666190701153903 (2019)

[17]      N.E.B. Saidu, N. Kavian, K. Leroy, C.  Jacob , C. Nicco, F. Batteux, J. Alexandre. Dimethyl fumarate, a  two-edged drug: Current status and future directions. Med Res Rev,  doi: 10.1002/med.21567. (2019)

[18]      N. Hamdi, Souad Chaouch, Ivan da Silva,  Mohamed Ezahri, Mohammed Lachkar, Rama Alhasan, Ahmad Yaman Abdin, Claus  Jacob and Brahim El Bali Synthesis, Structural Characterization, and  Biological Activities of Organically Templated Cobalt Phosphite (C4N2H14)Co(H2PO3)4·2H2O. Sci, 1(1), 13; (2019)

[19]      J. A. Tur, C. Jacob, P. Chaimbault, M.  Tadayyon, E. Richling, N. Hermans, C. N. dos Santos, M. Diederich, L.  Giblin, M. Elhabiri, C. Gaucher, P. Andreoletti, A. Fernandes, M.  Davies, A. Bartoszek, M. Cherkaoui-Malki. Personalized nutrition in  ageing society: redox control of major-age related diseases through the  NutRedOx Network (COST Action CA16112). Free Rad Res, doi.org/10.1080/10715762. 2019.1572890 (2019)

[20]      G. G. Dias, T. A. do Nascimento,  A. K.  A. de Almeida, A. C. S. Bombaça, R. F. S. Menna‐Barreto, C. Jacob, S.  Warratz, E.N. da Silva Júnior, L. Ackermann, Ruthenium(II)-Catalyzed C-H  Alkenylation of Quinones: Diversity-Oriented Strategy for Trypanocidal  Compounds. Eur J Org Chem. doi.org/10.1002/ejoc.201900004 (2019)

2018

 

[21]      R. Alhasan, A. Kharma, M. J. Nasim, A.  Y. Abdin, J. Bonetti, P. Giummelli, C. E.C.C. Ejike, P. Leroy, C.  Gaucher, C. Jacob, Flush with a flash: Natural three-component  antimicrobial combinations based on S-nitrosothiols, controlled  superoxide formation and “domino” reactions leading to peroxynitrite. Med. Chem. commun., 9(12), 1994-1999, (2018)

[22]      G.G. Dias, T. Rogge , R. Kuniyil, C.  Jacob, R.F.S. Menna-Barreto, E.N. da Silva Júnior, L. Ackermann,  Ruthenium-catalyzed C-H oxygenation of quinones by weak O-coordination  for potent trypanocidal agents. Chem Commun, 13;54(91):12840-12843. (2018)

[23]      R. Kurczab, W. Ali, D. Łażewska, M.  Kotańska, M. Jastrzębska-Więsek, G. Satała, M. Więcek, A. Lubelska, G.  Latacz, A. Partyka, M. Starek, M. Dąbrowska, A. Wesołowska, C. Jacob,  KI. Kieć-Kononowicz , J .Handzlik, Computer-Aided Studies for Novel  Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT₆ Serotonin Receptor  Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In  Vivo. Molecules. 23(10), 2529 (2018).

[24]      M. J. Nasim, P. Denezhkin, M. Sarfraz,  R. Leontiev, Y. Ney, A. Kharma, S. Griffin, M. I. Masood, C. Jacob, The  Small Matter of a Red Ox, a Particularly Sensitive Pink Cat, and the  Quest for the Yellow Stone of Wisdom. Curr. Pharmacol. Rep.  4:380–396 (2018)

[25]      K. Khairan, J. Vincent, C. Jacob, Study Cytotoxicity of Haarlem Oil by Crystal Violet Staining Assay. Res. J. Chem. Environ. 22, 198-202, (2018)

[26]      S. Shaaban, D. Vervandier-Fasseur,P.  Andreoletti, A. Zarrouk, P. Richard, A. Negm, G. Manolikakes, ,C. Jacob,  M. Cherkaoui-Malki, Cytoprotective and antioxidant properties of  organic selenides for the myelin-forming cells, oligodendrocytes. Bioorg. Chem.80, 43-56 (2018)

[27]      Y. Ney, M. J. Nasim, A. Kharma, L. A. Youssef, C. Jacob,  Small Molecule Catalysts with Therapeutic Potential Molecules; 23(4), 765 (2018)  

[28]      R. Leontiev, N. Hohaus, C. Jacob, M. C.  H. Gruhlke,  A. J. Slusarenko, A Comparison of the Antibacterial and  Antifungal Activities of Thiosulfinate Analogues of Allicin. Scientific Reports; 8, 6763 (2018)

[29]      S. Griffin, M. Sarfraz, S. F. Hartmann,  S. R. Pinnapireddy, M. J. Nasim, U. Bakowsky, M. C. M. Keck, C. Jacob,  Resuspendable Powders of Lyophilized Chalcogen Particles with Activity  against Microorganisms. Antioxidants;7(2), 23. (2018)

[30]      M. Sarfraz, S. Griffin, T. G. Sad, R.  Alhasan, M. J. Nasim, M. I. Masood, K. H. Schäfer, C. E.C.C. Ejike, C.  M. Keck ,C. Jacob, A. P. Ebokaiwe,  Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Into antimicrobial Materials. Antioxidants; 7(4), 60 (2018) 

[31]      S. Griffin, M. Sarfraz, V. Farida, M: J.  Nasim, A. P. Ebokaiwe,C. M. Keck, C. Jacob,  No time to waste organic  waste: Nanosizing converts remains of food processing into refined  materials, J Environ Manage, 210, 114-121 (2018)

[32]      G. A .M. Jardim, E. H. G. da Cruz, W. O.  Valença, D. J. B. Lima, B. C. Cavalcanti, C. Pessoa, J. Rafique, A. L.  Braga, C. Jacob, E. N. da Silva Júnior.  Synthesis of Selenium-Quinone  Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H  Bond Activation and Click Reactions. Molecules. ;23(1). (2018)

[33]      S. Griffin, M. I. Masood , M. J. Nasim,  M. Sarfraz, A. P.  Ebokaiwe, K-H. Schäfer, C. M. Keck, C. Jacob, Natural  Nanoparticles: A Particular Matter Inspired by Nature. Antioxidants.;7(1). (2018) 

[34]      M. J. Nasim, W. Ali, ,E.  Dominguez-Álvarez, E. N. da Silva Júnior, R. S. Z. Saleem, C. Jacob.  Reactive Selenium Species: Redox Modulation, Antioxidant, Antimicrobial  and Anticancer Activities. In book:  Organoselenium Compounds in Biology  and Medicine: Synthesis, Biological and Therapeutic Treatments. Royal Society of Chemistry, 277-302  (2018)

[35]      N.K. Tittikpina, F. Nana, S. Fontanay,  S. Philippot, K. Batawila, K. Akpagana, G. Kirsch, P. Chaimbault, C.  Jacob, R.E. Duval, Antibacterial activity and cytotoxicity of Pterocarpus erinaceus Poir extracts, fractions and isolated compounds. J Ethnopharmacol.212, 200-207. (2018) 

2017

 

[36]      K. Witek, M. J. Nasim, M. Bischoff, R.  Gaupp, P. Arsenyan, J. Vasiljeva, M. A. Marć , A. Olejarz, G. Latacz, K.  Kieć-Kononowicz, J. Handzlik, C.  Jacob, Selenazolinium Salts as "Small  Molecule Catalysts" with High Potency against ESKAPE Bacterial  Pathogens. Molecules.;22(12) (2017)

[37]      E. Y. Efe A. Mazumder, J. Lee,  A.  Gaigneaux F. Radogna, M. J. Nasim, Christo Christov , Claus Jacob, K.  Kim, M. Dicato, P. Chaimbault, C. Cerella, M. Diederich. Tubulin-binding  anticancer polysulfides induce cell death via mitotic arrest and  autophagic interference in colorectal cancer. Cancer Letters, 410, 139-157 (2017).

[38]      N. Koko Tittikpina, F. Nana, S.  Fontanay, S. Philippot, K. Batawila, K. Akpagana, G. Kirsch, P.  Chaimbault, C. Jacob, R. Emmanuel Duval, Antibacterial activity and  cytotoxicity of Pterocarpus erinaceus Poir extracts, fractions and  isolated compounds, Journal of Ethnopharmacology, (2017).

[39]      N. K. Tittikpina, W. Atakpama, H.  Pereki, M. J. Nasim, W. Ali, S. Fontanay, F. Nana, C. E. C. C.  Ejike,  G. Kirsch, R. E. Duval, P. Chaimbault, S. D. Karou, K. Batawila, K.  Akpagana, C. Jacob ‘Capiture’ plants with interesting biological  activities: a case to go. Open chemistry, 15, 1-11 (2017).

[40]      E. Jabeen, N. K. Janjua,  S. Ahmed, E.  Domínguez-Álvarez, C. Jacob. A selective and sensitive monitoring of the  OH radical using flavonoid-modified electrodes. Electrochimica Acta,  258 (20) , 228-235 ( 2017).

[41]      F. Albrecht, R. Leontiev, C. Jacob, A.J. Slusarenko, An Optimized Facile Procedure to Synthesize and Purify Allicin, Molecules, 22, (2017).

[42]      E.C. Estevam, S. Griffin, M.J. Nasim, P.  Denezhkin, R. Schneider, R. Lilischkis, E. Dominguez-Alvarez, K. Witek,  G. Latacz, C. Keck, K.H. Schafer, K. Kie-Kononowicz, J. Handzlik, C.  Jacob, Natural selenium particles from Staphylococcus carnosus: Hazards  or particles with particular promise?, Journal of Hazardous Materials, 324,  22-30, (2017).

[43]      W.O. Valenca, T.V. Baiju, F.G. Brito,  M.H. Araujo, C. Pessoa, B.C. Cavalcanti, C.A. de Simone, C. Jacob,  I.N.N. Namboothiri, E.N. da Silva, Synthesis of Quinone-Based  N-Sulfonyl-1,2,3-triazoles: Chemical Reactivity of Rh(II) Azavinyl  Carbenes and Antitumor Activity, Chemistry select, 2 4301-4308, (2017).

[44]      S. Griffin, R. Alkhayer, S. Mirzoyan, A.  Turabyan, P. Zucca, M. Sarfraz, M. J. Nasim, A. Trchounian, A.  Rescigno, C. M. Keck, C. Jacob, Nanosizing Cynomorium: Thumbs up for  Potential Antifungal Applications. Inventions, 2(3), 24 1-10, (2017).

[45]      G.I. Giles, M.J. Nasim, W. Ali, C. Jacob, The Reactive Sulfur Species Concept: 15 Years On. Antioxidants, 6(2):38, 1-29, (2017).

[46]      J. Rendeková, D. Vlasáková, P. Arsenyan,  J. Vasiljeva, M. J. Nasim, K. Witek, E. Domínguez-Álvarez, E.  Żesławska, D. Mániková, W. Tejchman, R. S. Z. Saleem, K. Rory, J.  Handzlik, M. Chovanec, The Selenium-Nitrogen Bond as Basis for Reactive  Selenium Species with Pronounced Antimicrobial Activity, Current Organic Synthesis, 14, (2017).

[47]      M. Grman, M. J. Nasim, R. Leontiev, A.  Misak, V. Jakusova, K. Ondrias, C. Jacob, Inorganic Reactive  Sulfur-Nitrogen Species: Intricate Release Mechanisms or Cacophony in  Yellow, Blue and Red?, Antioxidants, 6(1), (2017).

[48]      L. Faulstich, S. Griffin, M.J. Nasim,  M.I. Masood, W. Ali, S. Alhamound, Y. Omran, H. Kim, A. Kharma, K.H.  Schaefer, R. Lilischkis, M. Montenarh, C. Keck, C. Jacob, Nature's  Hat-trick: Can we use sulfur springs as ecological source for materials  with agricultural and medical applications?, International . Biodeterioration and  Biodegradation, 119, 678-686, (2017).

[49]      C. Zwergel, B. Czepukojc, E. Evain-Bana,  Z. Xu, G. Stazi, M. Mori,  A. Patsilinakos, A. Mai, B. Botta, R. Ragno,  D. Bagrel, G. Kirsch , P. Meiser, C. Jacob,  M. Montenarh,   S. Valente, Novel coumarin- and quinolinone-based polycycles as cell  division cycle 25-A and -C phosphatases inhibitors induce proliferation  arrest and apoptosis in cancer cells, European Journal of  Medicinal. Chemistry, 134, 316-333,  ( 2017).

2016

 

[50]      S. Griffin, N. K. Tittikpina, A.  Al-marby, R. Alkhayer, P. Denezhkin, K. Witek K. A. Gbogbo, K. Batawila,  R. E. Duval, M. J. Nasim, N. A. Awadh-Ali, G. Kirsch, P. Chaimbault,  K-H. Schäfer, C. M. Keck, J. Handzlik, C. Jacob,  Turning Waste into  Value: Nanosized Natural Plant Materials of Solanum incanum L. and  Pterocarpus erinaceus Poir with Promising Antimicrobial Activities, Pharmaceutics, 8(2): 11, (2016).

[51]      E. C. Estevam, L. Faulstich, S. Griffin,  T. Burkholz, C. Jacob. Polysulfides in Biology: From Intricate  Chemistry to an Astonishing Yet Hidden Biological Activity.  Current Organic Chemistry, 20(2) : 211 – 217, (2016).

[52]      E. Domínguez-Álvarez, M. Gajdács, G.  Spengler, J.A. Palop, M.A. Marć,  K. Kieć-Kononowicz,  L. Amaral, J.  Molnár, C. Jacob, J. Handzlik, C. Sanmartín, Identification of  selenocompounds with promising properties to reverse cancer multidrug  resistance, Bioorganic and Medicinal Chemistry Letters 26(12):2821-4, (2016).

[53]      O. Talhi, L. Brodziak-Jarosz, J.  Panning, B. Orlikova, C. Zwergel, T. Tzanova, S. Philippot, D.C. G. A.  Pinto, F. A. A. Paz, C. Gerhäuser, T. P. Dick, C. Jacob, M. Diederich,  D. Bagrel, G. Kirsch, A. M. S. Silva, One-Pot Synthesis of  Benzopyran-4-ones with Cancer Preventive and Therapeutic Potential. European Journal of  Organic Chemistry, 5, 965–975, (2016).

[54]      A. Al-Marby, C.E.C.C. Ejike, M.J. Nasim,  N.A. Awadh-Ali, R.A. Al-badani, G.M.A. Alghamdi , C. Jacob, Nematicidal  and antimicrobial activities of methanol extracts of 17 plants, of  importance in ethnopharmacology, obtained from the Arabian Peninsula, Journal of  Intercultural  Ethnopharmacology, 5(1): 1-6, (2016).

[55]      N.K. Tittikpina, C.E.C.C. Ejike, E.  Castelluci Estevam, M.J. Nasim, S. Griffin, P. Chaimbault, G. Kirsch, W.  Atakpama, K. Batawila, C. Jacob, Togo to go: Products and compounds  derived from local plants for the treatment of diseases endemic in  sub-Saharan Africa, African Journal of Traditional Complementary and  Alternative Medicine, 13(1):85-94, (2016).

2015

 

[56]      E. Castellucci Estevam, S. Griffin, M.J.  Nasim, D. Zieliński, J. Aszyk, M. Osowicka, N. Dawidowska, R. Idroes,  A. Bartoszek, C. Jacob, Inspired by Nature: The Use of Plant-derived  Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ, Natural Product Communication, 10(10), 1733-1738, (2015).

[57]      D. Rezk Allah, L. Schwind, I. Abu Asali,  J. Nasim, C. Jacob, C. Götz, M. Montenarh, A scent of therapy:  Synthetic polysulfanes with improved physico-chemical properties induce  apoptosis in human cancer cells, International  Journal of  Oncology, 47 (3), 991-1000, (2015).

[58]      C. Zwergel, S. Valente, C. Jacob, A. Mai, Emerging approaches for histone deacetylase inhibitor drug discovery, Expert Opinion on Drug Discovery, 10 (6), (2015).

[59]      M. Grman, E. Ondriasova, J. Nasim, C. Jacob, K. Ondrias, Decomposition of S-nitrosoglutathione by interaction with organic polysulfides and reduced thiols, Nitric Oxide, 47, (2015).

[60]      E. Castellucci Estevam , K. Witek , L.  Faulstich , M.J. Nasim , G. Latacz  , E. Domínguez-Álvarez  , K.  Kieć-Kononowicz , M. Demasi , J. Handzlik, C. Jacob, Aspects of a  Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living  Cells with Possible Implications for Drug Design, Molecules, 20, 13894-13912, (2015).

[61]      A.K.K. Bhasin, C. Jacob, F. Sasse, K.  Karaghiosoff , K.K. Bhasin, S.K. Mehta, Alka Sharma, Rishu, Design,  synthesis and characterization of picoline based organoselenium  compounds, 1,2-bis(pyridine-2/3/4-yl)methyl diselanes: X-ray crystal  structure of 1,2-bis(pyridine-3-y1) methyldiselane, Journal of Organometallic Chemistry, 785, 19-25, (2015).

2014

 [62]      E. Domínguez, D. Plano, M. Font, A.  Calvo, C. Prior, C. Jacob, J.A. Palop, C. Sanmartín, Synthesis and  antiproliferative activity of novel selenoester derivative, European Journal of Medicinal Chemistry, 73, 153-166 (2014).

[63]      O. Talhi, M. Schnekenburger, J. Panning,  D.G.C. Pinto, J.A. Fernandes, F.A. Almeida Paz, C. Jacob, M. Diederich,  A.M.S. Silva, Bis(4-hydroxy-2H-chromen-2-one): Synthesis and effects on  leukemic cell lines proliferation and NF-jB regulation, Bioorganic & Medicinal Chemistry, 22, 3008–3015 (2014)

[64]      A. Nucci, F.M. Merlo, M. De Nisco, S.  Pedatella, F. Rossi, C. Jacob, R. Caputo, A. Mastino,  Se-(2-aminoalkyl)selenocysteines as biochemical redox agents. A tool to  contrast cell injury induced by aflatoxin B1 in HepG2 cells, Amino Acids, 46(2), 459-470 (2014).

[65]      B. Czepukojc, A.K. Baltes, M. Kelkel, C.  Cerella, U.M. Viswanathan, F. Salm, T. Burkholz, C. Schneider, M.  Montenarh, M. Diederich, C. Jacob, Towards pharmaceutically useful,  redox-modulating polysulfanes based on naturally occurring garlic  compounds, Food and Chemical Toxicology, 64, 249–257 (2014).

[66]      P. Du, U.M. Viswanathan, K. Khairan, T.  Buric, N.E.B. Saidu, Z. Xu, B. Hanf, I. Bazukyan, A. Trchounian, F.  Hannemann, I. Bernhardt, T. Burkholz, B. Diesel, A.K. Kiemer, K.-H.  Schaefer, M. Montenarh, G. Kirsch, C. Jacob, Synthesis of amphiphilic,  chalcogen-based redox modulators with in vitro cytotoxic activity  against cancer cells, macrophages and microbes, Med.Chem.Comm., 5, 25-31 (2014).

[67]      P. Du, U.M. Viswanathan, Z. Xu, H.  Ebrahimnejad, B. Hanf, T. Burkholz, M. Schneider, I. Bernhardt, G.  Kirsch, M. Montenarh, C. Jacob, Synthesis and biological activity of  amphiphilic seleninic acid derivatives with considerable activity  against membranes, cancer cells and certain pathogenic microbes, Journal of Hazardous Materials, 269, 74–82 (2014).

[68]      P. Du, N.E:B. Saidu, J. Intemann, C.  Jacob, M. Montenarh, A new tellurium-containing amphiphilic molecule  induces apoptosis in HCT116 colon cancer cells, Biochim Biophys Acta, 1840(6), 1808-16 (2014).

[69]      T. Burkholz, M. Egert, C. Jacob,  Elektrochemische Dekontamination von leitenden Oberflächen: Von  grundlegenden Ideen zu neuen Ansätzen, WOMAG Oberflächen, Ausgabe 6/2014.

[70]      O. Talhi, M. Schnekenburger, J. Panning,  D.G.C. Pinto, J.A. Fernandes, F.A. Almeida Paz, C. Jacob, M. Diederich,  A.M.S. Silva, Bis(4-hydroxy-2H-chromen-2-one): Synthesis and effects on  leukemic cell lines proliferation and NF-κB regulation, Bioorganic & Medicinal Chemistry, 22 (11), 3008–3015 (2014).

[71]      V. Jamier, W. Marut, S. Valente, C.  Chéreau, S. Chouzenoux, C. Nicco, H. Lemaréchal, B. Weill, G. Kirsch, C.  Jacob, F. Batteux, Chalcone-Coumarin Derivatives as Potential  Anti-Cancer Drugs: An in vitro and in vivo Investigation, Anti-Cancer Agents in Medicinal Chemistry, 14(7), 963-74 (2014).

[72]      D. Mániková, L.M. Letavayová, D.  Vlasáková, P. Košík, E. Castellucci Estevam, M.J. Nasim, M. Gruhlke, A.  Slusarenko, T. Burkholz, C. Jacob, M. Chovanec, Intracellular  Diagnostics: Hunting for the Mode of Action of Redox-Modulating Selenium  Compounds in Selected Model Systems, Molecules, 19(8), 12258-12279 (2014).

[73]      C. Jacob, Special Issue: Redox Active Natural Products and Their Interaction with Cellular Signalling Pathways, Molecules, 19, 19588-19593 (2014).

[74]      L.-O. Klotz, X. Hou, C. Jacob, 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling, Molecules, 19, 14902-14918 (2014).

[75]      S. Shaaban, F. Sasse, T. Burkholz, C.  Jacob, Sulfur, selenium and tellurium pseudopeptides: Synthesis and  biological evaluation, Bioorganic & Medicinal Chemistry, 22, 3610–3619 (2014).

[76]      C. Jacob, G. Kirsch, A. Slusarenko, P.G.  Winyard, T. Burkholz (eds.), Recent Advances in Redox Active Plant and  Microbial Products: From basic chemistry to widespread applications in  Medicine and Agriculture, Springer Science, ISBN: 978-9401789523 (2015).

[77]      T. Burkholz, C. Jacob, A word on redox  activity, in: C. Jacob, G. Kirsch, A. Slusarenko, P.G. Winyard, T.  Burkholz (eds.), Recent Advances in Redox Active Plant and Microbial  Products: From basic chemistry to widespread applications in Medicine  and Agriculture, Springer Science (2015).

[78]      H. Ebrahimnejad, T. Burkholz, C. Jacob,  Treasures along the oligomeric road from flavonoids to polyphenols and  tannins, in: C. Jacob, G. Kirsch, A. Slusarenko, P.G. Winyard, T.  Burkholz (eds.), Recent Advances in Redox Active Plant and Microbial  Products: From basic chemistry to widespread applications in Medicine  and Agriculture, Springer Science (2015).

[79]      L.S. Sargsyan, K.R. Grigoryan, T.  Burkholz, S.A. Markarian, C. Jacob, Fluorescence characterisation of  human haemoglobin binding binding with tannic acid, Chemical Journal of  Armenia, 67(2-3), 181-187 (2014).

[80]      C. Jacob, L. Faulstich, M.J Nasim, T.  Burkholz, Von der Natur inspiriert: Redox-aktive Nahrungsbestandteile  (Metabolite) mit vielseitigen Anwendungen in der Medizin und  Landwirtschaft, Magazin Forschung, Ausgabe 2/2014 (2014)

2013

 [81]      W. Marut, V. Jamier, N. Kavian, A.  Servettaz, P. Winyard, P. Eggleton, A. Anwar, C. Nicco, C. Jacob, C.  Chéreau, B. Weill, F. Batteux, The Natural Organosulfur compound  Dipropyltetrasulfide Prevents HOCl-Induced Systemic Sclerosis in the  Mouse, Arthritis Research & Therapy, 15. 167 (2013).

[82]      L. Dejon, H. Mohammed, P. Du, C. Jacob, A. Speicher, Synthesis of tetrahydrochromenoindole derivatives from Robinia pseudoacacia, Med. Chem. Commun., (2013), DOI: 10.1039/C3MD00213F.

[83]      B. Czepukojc, M. Leroch, F. Salm, U.M.  Viswanathan, T. Burkholz, M. Hahn, C. Jacob, Antifungal activity of  tetrasulfanes against Botrytis cinerea, Natural Product Communications, 8(11), 1599-1603 (2013).

[84]      N.E.B. Saidu, I.A. Asali, B. Czepukojc,  B. Seitz, C. Jacob, M. Montenarh, Comparison between the effects of  diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19)  and HCT116 cells, Biochimica et Biophysica Acta, 1830(11), 5267-5276 (2013).

[85]      Y. Yu, B. Czepukojc, C. Jacob, Y. Jiang,  M. Zeller, C. Brückner, J.-L. Zhang, Porphothionolactones: Synthesis,  structure, physical, and chemical properties of a chemodosimeter for  hypochlorite, Organic & Biomolecular Chemistry, 11(28), 4613-21 (2013).

[86]      T. Burkholz, C. Jacob, Tellurium in Nature, in: R.H. Kretsinger, V.N. Uversky, E.A. Permyakov, (eds.), Encyclopaedia of Metalloproteins, 2163-2174 (2013).

[87]      M. Grman, A. Misak, C. Jacob, Z.  Tomaskova, A. Bertova, T. Burkholz, P. Docolomansky, L. Habala, K.  Ondrias, Low molecular thiols, pH and O2 modulate H2S induced •NO release from S-nitrosoglutathione, General Physiology and Biophysics, 32, 429–441 (2013).

[88]      B. Czepukojc, U.M. Viswanathan, A. Raza,  S. Ali, T. Burkholz, C Jacob, Tetrasulfanes as Selective Modulators of  the Cellular Thiolstat, Phosphorus, Sulfur, and Silicon and the related elements, 188(4), 446-453 (2013).

[89]      S. Valente, Z. Xu, E. Bana, C. Zwergel,  A. Mai, C. Jacob, P. Meiser, D. Bagrel, A.M.S. Silva, G. Kirsch,  Reactivity of 4-Vinyl-2H-1-benzopyran-2-ones in Diels–Alder  Cycloaddition Reactions: Access to Coumarin-Based Polycycles with Cdc25  Phosphatase-Inhibiting Activity, European Journal of Organic Chemistry, DOI: 10.1002/ejoc.201201736 (2013).

[90]      U.M. Viswanathan, T. Burkholz and C.  Jacob, Electrochemistry at the edge of reason: Chalcogen-based redox  systems in biochemistry and drug design, Zeitschrift für Physikalische Chemie, 227(5), 691-706 (2013).

[91]      E. Domínguez Álvarez, U.M. Viswanathan,  T. Burkholz, K. Khairan, C. Jacob, Bio-Electrochemistry and Chalcogens,  Chapter 7, in M. Schlesinger (ed.), Applications of Electrochemistry in Medicine, Modern Aspects of Electrochemistry, 56, 249-282 (2013).

[92]      N.E.B. Saidu, R. Touma, I.A. Asali, C.  Jacob, M. Montenarh, Diallyl tetrasulfane activates both the eIF2α and  Nrf2/HO-1 pathways, Biochimica et Biophysica Acta, 1830, 2214–2225 (2013).

[93]      P. Du, U.M. Viswanathan, Z. Xu, H.  Ebrahimnejad, B. Hanf, T. Burkholz, M. Schneider, I. Bernhardt, G.  Kirsch, M. Montenarh, C. Jacob, Emerging Biological Applications of  Chalcogens: Amphiphilic Selenic Acids with Multiple Impact on Living  Cells. in E.R. Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Proceedings of the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 59-68 (2013).

[94]      A.K.K. Bhasin, E. Arora, B. Hinkelmann,  F. Sasse, A. Raja, Y. Muthukumar, K.K. Bhasin, S.K. Mehta, T. Burkholz,  C. Jacob, Synthesis, Structural Elucidation and Anticarcinogenic  Potential of a New Selenium-incorporated Tricyclic Quinoline. in E.R.  Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Proceedings of the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 3-10 (2013).

[95]      C. Jacob, T. Burkholz, Emerging  biological applications of chalcogens: From the trivial to the more  exotic. in E.R. Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Abstract book from the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 37-38 (2013).

[96]      A.K.K. Bhasin, F. Sasse, C. Jacob, E.  Arora, S.K. Mehta, K.K. Bhasin, Design, synthesis and characterisation  of novel quinolone-based selenium compounds: X-ray structure of  3H-[1,2]diselenolo[3,4b]quinoline. in E.R. Rene, P. Kijjanapanich,  P.N.L. Lens (eds.), Abstract book from the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 37-38 (2013).

[97]      K.K. Bhasin, Ekta Arora, Alka S. Grover,  Jyoti, H. Singh, S.K. Mehta, A.K.K. Bhasin, C. Jacob, Synthesis and  characterization of new 2-pyrimidyl chalcogen (S, Se, Te) compounds:  X-ray crystal structure of bis(4,6-dimethyl-2-pyrimidyl)diselenide and  4,6-dimethyl-2-(phenylselanyl)pyrimidine, Journal of Organometallic Chemistry, 732, 137-141 (2013).

2012

 

[98]      M. Doering, B. Diesel, M.C.H. Gruhlke,  U.M. Viswanathan, T. Burkholz, A. Slusarenko, A.K. Kiemer and C. Jacob,  Selenium- and Tellurium-Containing Redox Modulators with Distinct  Activity against Macrophages: Possible Implications for the Treatment of  Inflammatory Diseases, Tetrahedron, 68, 10577-10585 (2012).

[99]      S. Shaaban, R. Diestel, B. Hinkelmann,  Y. Muthukumar, R.P. Verma, F. Sasse, C. Jacob, Novel peptidomimetic  compounds containing redox active chalcogens and quinones as potential  anticancer agents, European Journal of Medicinal Chemistry, 58, 192-205 (2012).

[100]   T. Schneider, Y. Muthukumar, B.  Hinkelmann, R. Franke, M. Döring, C. Jacob, F. Sasse, Deciphering  intracellular targets of organochalcogen based redox catalysts, Med.  Chem. Commun., 3, 784 (2012).

[101]   B. Czepukojc, T. Schneider, T. Burkholz,  V. Jamier, C. Jacob, Natural Sulfur Products as Redox Modulators and  Selective Inducers of Cell Death, in M. Diederich, K. Noworyta (eds.), Natural compounds as inducers of cell death: 1, Springer Science, 293-327 (2012).

[102]   M. Kelkel, C. Cerella, F. Mack, T.  Schneider, C. Jacob, M. Schumacher, M. Dicato, M. Diederich,  ROS-independent JNK activation and multisite phosphorylation of Bcl-2  link diallyl tetrasulfide-induced mitotic arrest to apoptosis, Carcinogenesis, 33(11), 2162–2171 (2012).

[103]   W. Marut, N. Kavian, A. Servettaz, C.  Nicco, L.A. Ba, M. Doering, C. Chereau, C. Jacob, B. Weill, F. Batteux,  The Organotelluride Catalyst (PHTE)(2)NQ Prevents HOCl-Induced Systemic  Sclerosis in Mouse, Journal of Investigative Dermatology, 132, 1125-1132 (2012).

[104]   L.A. Ba, T. Burkholz, T. Schneider, C.  Jacob, The Role of Cysteine in Amino Acids, Peptides and Proteins in  Organic Chemistry, in A.B. Hughes (ed.), Amino Acids, Peptides and  Proteins in Organic Chemistry: Analysis and Function of Amino Acids and  Peptides, 5, Wiley-VCH (2012).

[105]   C. Jacob, E. Battaglia, T. Burkholz, D.  Peng, D. Bagrel, M. Montenarh, Control of oxidative posttranslational  cysteine modifications: from intricate chemistry to widespread  biological and medical applications, Chemical Research in Toxicology, 25, 588-604 (2012).

[106]   Z. Xu, P. Du, P. Meiser and C. Jacob,  Proanthocyanidins: Oligomeric Structures with Unique Biochemical  Properties and Great Therapeutic Promise, Natural Product Communications, 7(3), 381-388 (2012).

[107]   N. Arshad, N.K. Janjua, A.Y. Khan, A.  Yaqub, T. Burkholz, C. Jacob, Natural Flavonoids Interact with  Dinitrobenzene System in Aprotic Media: An Electrochemical Probing, Natural Product Communications, 7(3), 311-315 (2012).

[108]   P.K. Agrawal, T. Burkholz and C. Jacob,  Revisit to 25R/25S Stereochemical Analysis of Spirostane-type Steroidal  Sapogenins and Steroidal Saponins via 1H NMR Chemical Shift Data, Natural Product Communications, 7(6), 709-711 (2012).

2012

 [109]   C. Jacob, Redox signalling via the cellular thiolstat, Biochemical Society Transactions, 39(5):1247-53 (2011).

[110]   R. Coriat, W. Marut, M. Leconte, L.A. Ba,  A. Vienne, C. Chéreau, J. Alexandre, B. Weill, M. Doering, C. Jacob, C.  Nicco, F. Batteux, The organotelluride catalyst LAB027 prevents colon  cancer growth in the mice, Cell Death and Disease, 2, 191 (2011).

[111]   C. Jacob, V. Jamier and L.A. Ba, Redox Active Secondary Metabolites, Current Opinion in Chemical Biology, 15, 149-155 (2011).

[112]   N. Lilienthal, C. Prinz, A.A. Peer-Zada,  M. Doering, L.A. Ba, M. Hallek, C. Jacob, M. Herling, Targeting the  disturbed redox equilibrium in chronic lymphocytic leukemia by novel  reactive oxygen species-catalytic ‘sensor/effector’ compounds, Leukemia & Lymphoma, 52(7), 1407–1411 (2011)

[113]   H.A. Mohammed, L.A. Ba, T. Burkholz, E.  Schumann, B. Diesel, J. Zapp, A.K. Kiemer, C. Ries, R.W. Hartmann, M.  Hosny and C. Jacob, Facile Synthesis of Chrysin-derivatives with  Promising Activities as Aromatase Inhibitors, Natural Product Communications, 6(1), 31-34 (2011).

[114]   E. Viry, A.Anwar, G. Kirsch, C.Jacob, M.  Diederich, D. Bagrel, Antiproliferative effect of natural tetrasulfides  in human breast cancer cells is mediated through the inhibition of the  cell division cycle 25 phosphatases, International Journal of Oncology, 38(4), 1103-1111 (2011).

[115]   T. Schneider, A. Baldauf, L.A. Ba, V.  Jamier, K. Yusuf, M.-B. Sarakbi, N. Reum, M. Schneider, A. Röseler, K.  Becker, T. Burkholz, P. G. Winyard, M. Kelkel, M. Diederich and C.  Jacob, Selective antimicrobial activity associated with sulfur  nanoparticles, Journal of Biomedical Nanotechnology, 7, 395-405 (2011).

[116]   T. Schneider, T., L.A. Ba, K. Khairan, C.  Zwergel, N.D. Bach, I. Bernhardt, W. Brandt, L. Wessjohann, M.  Diederich, C. Jacob, Interactions of polysulfanes with components of red  blood cells, Med. Chem. Commun., 2, 196-200 (2011).

[117]   C. Jacob, L.A. Ba, Open season for hunting  and trapping posttranslational cysteine modifications in proteins and  enzymes, ChemBioChem, 12, 841-844 (2011).

[118]   C. Cerella, M. Dicato, C. Jacob, M.  Diederich, Chemical Properties and Mechanisms Determining the  Anti-Cancer Action of Garlic-Derived Organic Sulfur Compounds, Anti-Cancer Agents in Medicinal Chemistry, 5, 267-271 (2011).

[119]   N.K. Janjua, A. Shaheen, A. Yaqub, F.  Perveen, S. Sabahat, M. Mumtaz, C. Jacob, L.A. Ba, H.A. Mohammed,  Flavonoid–DNA binding studies and thermodynamic parameters, Spectrochimica Acta Part A, 79, 1600–1604 (2011).

2010

 [120]   M.C.H. Gruhlke, D. Portz, M. Stitz, A.  Anwar, T. Schneider, C. Jacob, N.L. Schlaich, A.J. Slusarenko, Allicin  disrupts the cell's electrochemical potential and induces apoptosis in  yeast, Free Radical Biology and Medicine, 49, 1916-1924 (2010).

[121]   M. Kelkel, C. Jacob, M. Dicato and M.  Diederich, Potential of the dietary antioxidants resveratrol and  curcumin in prevention and treatment of hematologic molecules, Molecules, 15, 7035-7074 (2010).

[122]   M. Doering, L.A. Ba, N. Lilienthal, C.  Nicco, C. Scherer, M. Abbas, A.A. Peer Zada, R. Coriat, T. Burkholz, L.  Wessjohann, M. Diederich, F. Batteux, M. Herling and C. Jacob, Synthesis  and selective anti-cancer activity of novel organotellurium based redox  catalysts, Journal of Medicinal Chemistry, 53, 6954-6963 (2010).

[123]   V. Jamier, L.A. Ba and C. Jacob, Selenium- and Tellurium-containing Multifunctional Redox Agents, Chemistry - A European Journal, 16, 10920-10928 (2010).

[124]   L.A. Ba, V. Jamier, M. Doering and C. Jacob, Tellurium: An element with great potency and potential, Organic & Biomolecular Chemistry, 8, 4203-4216 (2010), Invited Emerging Area manuscript.

[125]   C. Busch, C. Jacob, A. Anwar, T. Burkholz,  L.A. Ba, C. Cerella, M. Diederich, W. Brandt, L. Wessjohann and M.  Montenarh, Diallylpolysulfides induce growth arrest and apoptosis, International Journal of Oncology, 36(3), 743-749 (2010).

[126]   C. Scherer, C. Jacob, M. Dicato and M.  Diederich, Allylsulfides as bioactive compounds with chemotherapeutic  and/or chemopreventive effects, in: I. Rasooli (ed.) Phytochemicals - Bioactivities and Impact on Health, ISBN 978-953-307-424-5, InTech (2010).

For publication before 2010 please contact us by email

please cotact us for publication (125 publications) between 1990 and 2010