Prof. Dr. Claus Jacob Research Group

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Academiacs International

Academiacs InternationalAcademiacs InternationalAcademiacs International
  • Home
  • Ukraine Digital
  • About Us
  • Projects
  • Research
  • Publications
  • Downloads
  • Global Classroom
  • Help Desk
  • News and updates

2024

[1]   Agrawal, P.K.; Blunden, G.; Jacob, C. Antiviral Significance of Isoquercetin (Quercetin-3-O-Glucoside) With Special Reference to Its Anti-Coronaviral Potential. Natural Product Communications 2024, 19, 1934578X231219560, doi:10.1177/1934578X231219560. 

[2]   Abdin, A.Y.; Jacob, C. Sci Reloaded: Introducing the New Aims and Scope. Sci 2024, 6, 8, doi:10.3390/sci6010008. 

[3]    Machado, L.A.; Pereira, C.L.M.; Souza, A.C.G. de; Ferreira, E.A.; Marques, F.F.C.; Orestes, E.; Araujo, M.H.; Paiva, K.L.R.; Mesquita, M.S.; Báo, S.N.; et al. BODIPYs as Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets: Photophysical and Computational Studies. Current Organic Synthesis 21, 1–17, doi:10.2174/0115701794294862240322040633.

[4]   Razouk, A.; Tiganescu, E.; Von Glahn, A.J.; Abdin, A.Y.; Nasim, M.J.; Jacob, C. The Future in the Litter Bin -Bioconversion of Food Waste as Driver of a Circular Bioeconomy. Front. Nutr. 2024, 11, doi:10.3389/fnut.2024.1325190. 

2023

  

[1] Thaher, B. A. Al-Masri, I., Wahedy, K., Morjan, R., Aliwaini, S., Al Atter, I.M., Elmabhouh, A.A., ibwaini, A.K.A., Alkhaldi, S.L., Qeshta, B. and Jacob, C. Synthesis and bioassay of 3-Aryl -1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]- triazin-4(3H)-ones as anti-cancer agents. Naunyn. Schmiedebergs Arch. Pharmacol. (2023) doi:10.1007/s00210-023-02433-5.

[2]  Oliveira, J.C.; de Carvalho, R.L.; Sampaio, H.G.S.; Honorato, J.; Ellena, J.A.; Martins, F.T.; Pereira, J.V.M.; Costa, P.M.S.; Pessoa, C.; Ferreira, R.S.; Araújo, M.H.; .; da Silva Júnior, E.N. It Takes Two to Tango, Part II: Synthesis of A-Ring Functionalised Quinones Containing Two Redox-Active Centres with Antitumour Activities. Molecules. 28, 2222. https://doi.org/10.3390/molecules28052222. (2023)

[3]  Castiello, C., Junghanns, P., Mergel, A., Jacob, C., Ducho, C., Valente, S., Rotili, D., Zwergel, C. and Mai, A. GreenMedChem-the challenge in the next decade toward eco-friendly compounds and processes in drug design. Green Chemistry. 25, 2109-2169. (2023)

[4]  Sarfraz, M., Nasim, M. J., Gruhlke, M. C. H., Handzlik, J. & Jacob, C. To Cut the Mustard: Antimicrobial Activity of Selenocyanates on the Plate and in the Gas Phase. Antibiotics 12, 290 (2023).

[5]  Abdin, A. Y. & Jacob, C. Make a Stand(ard) for Science. Sci 5, 7 (2023).

[6]   Witek, K.; Kaczor, A.; Żesławska, E.; Podlewska, S.; Marć, M.A.; Czarnota-Łydka, K.; Nitek, W.; Latacz, G.; Tejchman, W.; Bischoff, M.; et al. Chalcogen-Varied Imidazolone Derivatives as Antibiotic Resistance Breakers in Staphylococcus Aureus Strains. Antibiotics 2023, 12, 1618, doi:10.3390/antibiotics12111618. 

[7]   Meva, F.E.; Djomaha, L.D.Y.; Nasim, M.J.; Ntoumba, A.A.; Kouemegne, A.M.H.; Ottou, P.B.M.; Loe, G.E.; Dibong, S.D.; Jacob, C. Bead Milling Liberates the Antioxidant Properties of Nanosized Tubers of Vernonia Guineensis Benth (Asteraceae). Journal of Bioresources and Environmental Sciences 2024, 3, 14–26, doi:10.61435/jbes.2024.19919. 

[8]   Alhasan, R.; Martins, G.M.; de Castro, P.P.; Saleem, R.S.Z.; Zaiter, A.; Fries-Raeth, I.; Kleinclauss, A.; Perrin-Sarrado, C.; Chaimbault, P.; da Silva Júnior, E.N.; et al. Selenoneine-Inspired Selenohydantoins with Glutathione Peroxidase-like Activity. Bioorganic & Medicinal Chemistry 2023, 94, 117479, doi:10.1016/j.bmc.2023.117479. 

[9]   Marć, M.A.; Domínguez-Álvarez, E.; Jacob, C. Bioorganic Chemistry: Current and Future Perspectives. Molecules 2023, 28, 5959, doi:10.3390/molecules28165959. 

[10]   Tiganescu, E.; Abdin, A.Y.; Razouk, A.; Nasim, M.J.; Jacob, C. The Redox Riddle of Selenium Sulfide. Current Opinion in Chemical Biology 2023, 76, 102365, doi:10.1016/j.cbpa.2023.102365. 

[11]   Antibacterial Activity of N-Hexane Dragon’s Blood Resin Extract (Daemonorops Draco Wild Blume) from Bener Meriah, Aceh Province, Indonesia | Malacca Pharmaceutics. 

[12]   Abdin, A.Y.; De Pretis, F.; Landes, J. Fast Methods for Drug Approval: Research Perspectives for Pandemic Preparedness. International Journal of Environmental Research and Public Health 2023, 20, 2404, doi:10.3390/ijerph20032404. 

2022

  

[1] Tittikpina, N. K., Kirsch, G., Duval, R. E., Chaimbault, P. & Jacob, C. Daniellia oliveri (Rolfe) Hutch and Dalziel: Antimicrobial Activities, Cytotoxicity Evaluation, and Phytochemical Identification by GC-MS. Antibiotics 11, 1699 (2022).

[2]  Hovhannisyan, Z.; Timotina, M.; Manoyan, J.; Gabrielyan, L.; Petrosyan, M.; Kusznierewicz, B.; Bartoszek, A.; Jacob, C.; Ginovyan, M.; Trchounian, K.; Sahakyan, N.; Nasim, M.J. Ribes nigrum L. Extract-Mediated Green Synthesis and Antibacterial Action Mechanisms of Silver Nanoparticles. Antibiotics, 11, 1415. https://doi.org/10.3390/antibiotics11101415 (2022).

[3]  Ali, W; Garbo, S.; Kincses, A.; Nové, M.; Spengler, G.; Di Bello, E.; Honkisz-Orzechowska, E.; Karcz, T.; Szymańska, E.; Żesławska, E.; Starek, M:; Dąbrowska, M.; Nitek, W.; Kucwaj-Brysz, K.; Pyka, P.; Fioravanti, R.; Jacob, C.; Battistelli, C.; Zwergel, C.;  Handzlik, J. Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma. Eur. J. Med. Chem. 243, 114761 (2022).

[4]  Tiganescu, E.; Lämmermann, M.A.; Ney, Y.; Abdin, A.Y.; Nasim, M.J.; Jacob, C. A Whiff of Sulfur: One Wind a Day Keeps the Doctor Away. Antioxidants 2022, 11, 1036. https://doi.org/10.3390/antiox11061036 (2022).

[5]  Domínguez-Álvarez, E., Rácz, B., Marć, M. A., Nasim, M. J., Szemerédi, N., Viktorová, J., Jacob, C., & Spengler, G Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents. Drug Resist. Updat. 63, 100844 (2022).

[6]  Merten, D., Erman, L., Marabelli, G.P., Leners, B., Ney, Y., Nasim, M.J., Jacob, C., Tchoumtchoua, J., Cajot, S. and Bohn, T. Potential health effects of brewers’ spent grain as a functional food ingredient assessed by markers of oxidative stress and inflammation following gastro-intestinal digestion and in a cell model of the small intestine. Food Funct. 13, 5327–5342 (2022).

[7]  Abdin, A. Y., Jacob, C. Sci: An Inclusive, Multidisciplinary Scientific Journal. Sci 4, 10 (2022).

[8]  Hamdi, N. et al. Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H2DAB)[Co(H2PO3)4]·2H2O. Sci 4, 5 (2022).

2021

  

[1] C. Jacob, A.Y. Abdin, F. Köhler F, W. Maret. Bert Vallee—A 20th Century Adventure(r) in Zincology. International Journal of Molecular Sciences. 22(24):13393. (2021)

[2] P.Yeboah, D.B. Daliri, A.Y. Abdin, E. Appiah-Brempong, W. Pitsch, A.B. Panyin, E.B.A. Adusei, A. Razouk , M.J. Nasim, C. Jacob. Knowledge into the Practice against COVID-19: A Cross-Sectional Study from Ghana. International Journal of Environmental Research and Public Health. 18(24):12902. (2021)

[3] M.J. Nasim, M.M. Zuraik, A.Y. Abdin, Y. Ney, C. Jacob. Selenomethionine: A Pink Trojan Redox Horse with Implications in Aging and Various Age-Related Diseases. Antioxidants. 10(6):882 (2021). 

[4] D.J. Lima, R.G. Almeida, G.A. Jardim, B.P. Barbosa, A.C. Santos, W.O. Valença, M.R. Scheide, C.C. Gatto, G.G. de Carvalho, P.M. Costa, C. Pessoa, L.M.P. Cynthia, C. Jacob, A. L. Braga, E. N. da Silva Júnior It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity. RSC Medicinal Chemistry, 12(10), pp.1709-1721. (2021)

[5] A.Y. Abdin, C. Jacob, L. Kästner. The Enigmatic Metallothioneins: A Case of Upward-Looking Research. International Journal of Molecular Sciences. 22 (11), 5984 (2021).

[6] A. Misak, V. Brezova, M. Chovanec, K. Luspai , M.J. Nasim, M. Grman, L. Tomasova, C. Jacob, K. Ondrias. EPR Study of KO2 as a Source of Superoxide and •BMPO-OH/OOH Radical That Cleaves Plasmid DNA and Detects Radical Interaction with H2S and Se-Derivatives. Antioxidants. 10(8):1286. (2021).

[7] A.Y. Abdin, M.J. Nasim, Y. Ney, C. Jacob. The Pioneering Role of Sci in Post Publication Public Peer Review (P4R). Publications,9, 13 (2021).

[8] A. Kaczor, K. Witek, S. Podlewska, V. Sinou, J. Czekajewska, E. Żesławska, A. Doroz-Płonka, A. Lubelska, G. Latacz, W. Nitek, M. Bischoff, S. Alibert, J-M. Pagès, C. Jacob, E. Karczewska, J-M. Bolla, J. Handzlik. Molecular Insights into an Antibiotic Enhancer Action of New Morpholine-Containing 5-Arylideneimidazolones in the Fight against MDR Bacteria. International Journal of Molecular Sciences.22(4):2062 (2021).

[9] A.K. Darkal, M.M. Zuraik, Y. Ney, M.J. Nasim, C. Jacob. Unleashing the Biological Potential of Fomes fomentarius via Dry and Wet Milling. Antioxidants. 10(2):303 (2021).

[10] T.G. Sad, I. Djafaridze, A. Kalandia, M. Vanidze, K. Smilkov, C. Jacob. Antioxidant Properties of Western Georgia Native Khechechuri Pear. Sci. 1(2), 44 (2021).

[11] K. Khairan, R. Idroes, T. E. Tallei, M. J. Nasim, C. Jacob. Bioactive Compounds from Medicinal Plants and Their Possible Effect as Therapeutic Agents against COVID-19: A Review. Current Nutrition & Food Science 17: 1 (2021). 

2020

 1.  Abdin, A.Y.; Yeboah, P.; Jacob, C. Chemical Impurities: An Epistemological Riddle with Serious Side Effects. International Journal of Environmental Research and Public Health 2020, 17, 1030, doi:10.3390/ijerph17031030.

2.  Salman, W.; Ney, Y.; Nasim, M.J.; Bohn, T.; Jacob, C. Turning Apparent Waste into New Value: Up-Cycling Strategies Exemplified by Brewer’s Spent Grains (BSG). Current Nutraceuticals 1, 6–13, doi:10.2174/2665978601666200220100600.

3.  Electrochemical Selenation/Cyclization of Quinones: A Rapid, Green and Efficient Access to Functionalized Trypanocidal and Antitumor Compounds - Kharma - 2020 - European Journal of Organic Chemistry - Wiley Online Library Available online: https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202000216 (accessed on 6 May 2024).

4.  Abdin, A.Y.; Jacob, C.; Kästner, L. Disambiguating “Mechanisms” in Pharmacy: Lessons from Mechanist Philosophy of Science. International Journal of Environmental Research and Public Health 2020, 17, 1833, doi:10.3390/ijerph17061833.

5.  Jacob, C. Introductory Note to Current Nutraceuticals. Current Nutraceuticals 1, 1–3, doi:10.2174/266597860101200324104126.

6.  da Silva Júnior, E.N.; de Carvalho, R.L.; Almeida, R.G.; Rosa, L.G.; Fantuzzi, F.; Rogge, T.; Costa, P.M.S.; Pessoa, C.; Jacob, C.; Ackermann, L. Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds. Chemistry – A European Journal 2020, 26, 10981–10986, doi:10.1002/chem.202001434.

7.  Sarfraz, M.; Nasim, M.J.; Jacob, C.; Gruhlke, M.C.H. Efficacy of Allicin against Plant Pathogenic Fungi and Unveiling the Underlying Mode of Action Employing Yeast Based Chemogenetic Profiling Approach. Applied Sciences 2020, 10, 2563, doi:10.3390/app10072563.

8.  Zielinski, D.; Fraczyk, J.; Debowski, M.; Zielinski, M.; Kaminski, Z.J.; Kregiel, D.; Jacob, C.; Kolesinska, B. Biological Activity of Hydrophilic Extract of Chlorella Vulgaris Grown on Post-Fermentation Leachate from a Biogas Plant Supplied with Stillage and Maize Silage. Molecules 2020, 25, 1790, doi:10.3390/molecules25081790.

9.  Ali, W.; Spengler, G.; Kincses, A.; Nové, M.; Battistelli, C.; Latacz, G.; Starek, M.; Dąbrowska, M.; Honkisz-Orzechowska, E.; Romanelli, A.; et al. Discovery of Phenylselenoether-Hydantoin Hybrids as ABCB1 Efflux Pump Modulating Agents with Cytotoxic and Antiproliferative Actions in Resistant T-Lymphoma. European Journal of Medicinal Chemistry 2020, 200, 112435, doi:10.1016/j.ejmech.2020.112435.

10.  Sahakyan, N.; Bartoszek, A.; Jacob, C.; Petrosyan, M.; Trchounian, A. Bioavailability of Tannins and Other Oligomeric Polyphenols: A Still to Be Studied Phenomenon. Curr Pharmacol Rep 2020, 6, 131–136, doi:10.1007/s40495-020-00217-6.

11.  Kharma, A.; Jacob, C.; Bozzi, Í.A.O.; Jardim, G.A.M.; Braga, A.L.; Salomão, K.; Gatto, C.C.; Silva, M.F.S.; Pessoa, C.; Stangier, M.; et al. Front Cover: Electrochemical Selenation/Cyclization of Quinones: A Rapid, Green and Efficient Access to Functionalized Trypanocidal and Antitumor Compounds (Eur. J. Org. Chem. 29/2020). European Journal of Organic Chemistry 2020, 2020, 4433–4433, doi:10.1002/ejoc.202001035.

12.  Hambardzumyan, S.; Sahakyan, N.; Petrosyan, M.; Nasim, M.J.; Jacob, C.; Trchounian, A. Origanum Vulgare L. Extract-Mediated Synthesis of Silver Nanoparticles, Their Characterization and Antibacterial Activities. AMB Express 2020, 10, 162, doi:10.1186/s13568-020-01100-9.

13.  Upcycling Culinary Organic Waste: Production of Plant Particles from Potato and Carrot Peels to Improve Antioxidative Capacity | Bentham Science Available online: https://www.eurekaselect.com/article/110256 (accessed on 6 May 2024).

14.  Abraham, A.M.; Alnemari, R.M.; Jacob, C.; Keck, C.M. PlantCrystals—Nanosized Plant Material for Improved Bioefficacy of Medical Plants. Materials 2020, 13, 4368, doi:10.3390/ma13194368.

15.  Vaso, M.; Ali, W.; Masood, M.I.; Nasim, M.J.; Lilischkis, R.; Schäfer, K.-H.; Schneider, M.; Jacob*, V.T.P. and C. Nanosizing Nigella: A Cool Alternative to Liberate Biological Activity Available online: https://www.eurekaselect.com/186418/article (accessed on 24 November 2020).

16.  Vazquez, F.; Lin, S.-K.; Jacob, C. Changing Sci from Post-Publication Peer-Review to Single-Blind Peer-Review. Sci 2020, 2, 82, doi:10.3390/sci2040082.

17.  Sudoł, S.; Kucwaj-Brysz, K.; Ali, W.; Satała, G.; Jacob, C.; Handzlik, J. Se-Containing 5-HT6R Ligands in Search for Efficient Therapy of Alzheimer’s Disease. 2020, doi:10.3390/ECMC2020-07698.

18.  Ghanem, A.A.; Nasim, M.J.; Alnahas, F.; Ney, Y.; Weiss, A.-V.; Koch, M.; Schneider, M.; Jacob, C. Incredible Edible Selenium Nanoparticles Produced by Food-Grade Microorganisms. Current Nutraceuticals 2, 135–144, doi:10.2174/2665978601999201113152144.

19.  Azubuike-Osu, S.O.; Ohanenye, I.C.; Jacob, C.; Ejike, C.E.C.C.; Udenigwe, C.C. Beneficial Role of Vitexin and Isovitexin Flavonoids in the Vascular Endothelium and Cardiovascular System. Current Nutraceuticals 2, 127–134, doi:10.2174/2665978601999201105160405.

20.  Marć, M.A.; Kincses, A.; Rácz, B.; Nasim, M.J.; Sarfraz, M.; Lázaro-Milla, C.; Domínguez-Álvarez, E.; Jacob, C.; Spengler, G.; Almendros, P. Antimicrobial, Anticancer and Multidrug-Resistant Reversing Activity of Novel Oxygen-, Sulfur- and Selenoflavones and Bioisosteric Analogues. Pharmaceuticals 2020, 13, 453, doi:10.3390/ph13120453.

2019

 

[1]  Sahakyan, N.; Petrosyan, M.; Koss-Mikołajczyk, I.; Bartoszek, A.; Sad, T.G.; Nasim, M.J.; Vanidze, M.; Kalandia, A.; Jacob, C.; Trchounian, A. The Caucasian Flora: A Still-to-Be-Discovered Rich Source of Antioxidants. Free Radical Research 2019, 53, 1153–1162, doi:10.1080/10715762.2019.1648799.
[2]  Efe, E.Y.; Mazumder, A.; Lee, J.-Y.; Gaigneaux, A.; Radogna, F.; Nassim, M.J.; Christov, C.; Jacob, C.; Kim, K.-W.; Mario, D.; et al. Les Polysulfides Anticancéreux Induisent l’apoptose Des Cellules Issues de Cancers Colorectaux Par Arrêt de La Division Cellulaire et Du Flux Autophagique. Morphologie 2019, 103, 69–70, doi:10.1016/j.morpho.2019.10.003.
[3]   M. Sarfraz, M. J. Nasim, C. Jacob, M. C.H.  Gruhlke. Yeast Chemogenetic Screening as a Tool to Unravel the  Antifungal Mode of Action of Two Selected Selenocyanates. Appl. Sci.-Basel  (2019)
[4]   N. Sahakyan, M. Petrosyan, I.  Koss-Mikołajczyk, A. Bartoszek, T. G. Sad, M. J. Nasim, M. Vanidze, A.  Kalandia, C. Jacob, A. Trchounian. The Caucasian flora: a  still-to-be-discovered rich source of antioxidants. Free Rad Res. (2019)
[5]   M. J. Nasim, K. Witek, A. Kincses, A. Y.  Abdin, E. Żesławska, M. A. Marć, M. Gajdács, G. Spengler, W. Nitek, G.  Latacz, E. Karczewska, K. Kieć-Kononowicz, J. Handzlik, C. Jacob.  Pronounced activity of aromatic selenocyanates against multidrug  resistant ESKAPE bacteria. New J Chem, 43, 6021-6031. (2019)
[6]   S.L. Wadgaonkar, Y.V. Nancharaiah, C. Jacob,  G. Esposito, P.N.L. Lens. Microbial transformation of Se oxyanions in  cultures of Delftia lacustris grown under aerobic conditions. J Microbiol, 57(5):362-371..(2019)
[7]   C. Jacob, M. Rittman, F. Vazquez, A:Y.  Abdin. Evolution of Sci's Community-Driven Post-Publication Peer-Review. Sci, 1, 16. (2019)
[8]   A. Kharma, M. Grman, A. Misak, E.  Domínguez-Álvarez, M.J. Nasim, K. Ondrias, M. Chovanec, C. Jacob.  Inorganic Polysulfides and Related Reactive Sulfur–Selenium Species from  the Perspective of Chemistry. Molecules, 24, 1359. (2019)
[9]   R. Alhasan, M. J. Nasim, C. Jacob, C.  Gaucher. Selenoneine: a Unique Reactive Selenium Species From the Blood  of Tuna With Implications for Human Diseases. Curr Pharmacol Rep 5: 163. (2019)
[10]        K. Khairan,  L.A. Ba, T.  Burkholz,M.Leroch, M.Hahn, T. Schwab, M.Klotz, K-H. Schaefer, C. Jacob.  Electrochemical Potential-Biological Activity Relationships of Cyclic  Sulfur-Containing Molecules Against Steinernema feltiae, Botrytis  cinerea, and Neuro 2a Cell Line. Curr Pharmacol Rep 5: 174. (2019)
[11]        C.Aloke, I.I.Ezeigbo, I.C. Ohanenye,  C.C.Udenigwe, C. Jacob, C.E.C.C. Ejike. A Small Green Red-Ox Carries a  Bright Medical Future for Sub-Saharan Africa. Curr Pharmacol Rep 5: 245 (2019)
[12]      Nasim, M.J.; Alhasan, R.; Abdin, A.Y.;  Alnahas, F.; Jacob, C. Inspired by Nature: Redox Modulators and Natural  Nanoparticles. Proceedings, 11, 24 (2019)
[13]      N.K.Tittikpina, L.  P.Sandjo, F. Nana,  V. Vaillant, S. Fontanaya, S. Philippot, Y. M.Dioph, K. Batawila, K.  Akpagana, G. Kirsch, R. E. Duval, C. Jacob, P. Chaimbault. Investigation  of the antifungal activity of Pterocarpus erinaceus led to the  identification of two new diarylpropanoids from its roots. Phytochem Lett 32, 110-114. (2019)
[14]      E.N. da Silva Júnior, G.A.M. Jardim, C.  Jacob, U. Dhawa, L. Ackermann, S.L. de Castro. Synthesis of quinones  with highlighted biological applications: A critical update on the  strategies towards bioactive compounds with emphasis on lapachones. Eur J Med Chem ;179:863-915. doi: 10.1016/j.ejmech.2019.06.056 (2019)
[15]      A.Y. Abdin, D. Auker-Howlett, J. Landes,  G. Mulla, C. Jacob, B. Osimani. Reviewing the mechanistic evidence  assessors E-Synthesis and EBM+: A case study of amoxicillin and Drug  Reaction with Eosinophilia and Systemic Symptoms (DRESS). Curr Pharm Des doi: 10.2174/1381612825666190628160603 (2019)
[16]      A. Kharma, A. Misak, M. Grman, V.  Brezova, L. Kurakova, P. Baráth,  C. Jacob, M. Chovanec, K. Ondrias,  E.  Domínguez-Álvarez. Release of reactive selenium species from phthalic  selenoanhydride in the presence of hydrogen sulfide and glutathione with  implications for cancer research. New J Chem 43, 11771-117832019 (2019)
[17]      D. Kołodziejski, I. Koss-Mikołajczyk,  A.Y. Abdin, C. Jacob, A. Bartoszek. Chemical aspects of biological  activity of isothiocyanates and indoles, the products of glucosinolate  decomposition. Curr Pharm Des. doi: 10.2174/1381612825666190701151644 (2019)
[18]      R. Alhasan, A. Kharma, P. Leroy, C. Jacob, C. Gaucher. Selenium donors at the junction of inflammatory diseases. Curr Pharm Des. doi: 10.2174/1381612825666190701153903 (2019)
[19]      N.E.B. Saidu, N. Kavian, K. Leroy, C.  Jacob , C. Nicco, F. Batteux, J. Alexandre. Dimethyl fumarate, a  two-edged drug: Current status and future directions. Med Res Rev,  doi: 10.1002/med.21567. (2019)
[20]      N. Hamdi, Souad Chaouch, Ivan da Silva,  Mohamed Ezahri, Mohammed Lachkar, Rama Alhasan, Ahmad Yaman Abdin, Claus  Jacob and Brahim El Bali Synthesis, Structural Characterization, and  Biological Activities of Organically Templated Cobalt Phosphite (C4N2H14)Co(H2PO3)4·2H2O. Sci, 1(1), 13; (2019)
[21]      J. A. Tur, C. Jacob, P. Chaimbault, M.  Tadayyon, E. Richling, N. Hermans, C. N. dos Santos, M. Diederich, L.  Giblin, M. Elhabiri, C. Gaucher, P. Andreoletti, A. Fernandes, M.  Davies, A. Bartoszek, M. Cherkaoui-Malki. Personalized nutrition in  ageing society: redox control of major-age related diseases through the  NutRedOx Network (COST Action CA16112). Free Rad Res, doi.org/10.1080/10715762. 2019.1572890 (2019)
[22]      G. G. Dias, T. A. do Nascimento,  A. K.  A. de Almeida, A. C. S. Bombaça, R. F. S. Menna‐Barreto, C. Jacob, S.  Warratz, E.N. da Silva Júnior, L. Ackermann, Ruthenium(II)-Catalyzed C-H  Alkenylation of Quinones: Diversity-Oriented Strategy for Trypanocidal  Compounds. Eur J Org Chem. doi.org/10.1002/ejoc.201900004 (2019)

2018

 

[21]      R. Alhasan, A. Kharma, M. J. Nasim, A.  Y. Abdin, J. Bonetti, P. Giummelli, C. E.C.C. Ejike, P. Leroy, C.  Gaucher, C. Jacob, Flush with a flash: Natural three-component  antimicrobial combinations based on S-nitrosothiols, controlled  superoxide formation and “domino” reactions leading to peroxynitrite. Med. Chem. commun., 9(12), 1994-1999, (2018)

[22]      G.G. Dias, T. Rogge , R. Kuniyil, C.  Jacob, R.F.S. Menna-Barreto, E.N. da Silva Júnior, L. Ackermann,  Ruthenium-catalyzed C-H oxygenation of quinones by weak O-coordination  for potent trypanocidal agents. Chem Commun, 13;54(91):12840-12843. (2018)

[23]      R. Kurczab, W. Ali, D. Łażewska, M.  Kotańska, M. Jastrzębska-Więsek, G. Satała, M. Więcek, A. Lubelska, G.  Latacz, A. Partyka, M. Starek, M. Dąbrowska, A. Wesołowska, C. Jacob,  KI. Kieć-Kononowicz , J .Handzlik, Computer-Aided Studies for Novel  Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT₆ Serotonin Receptor  Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In  Vivo. Molecules. 23(10), 2529 (2018).

[24]      M. J. Nasim, P. Denezhkin, M. Sarfraz,  R. Leontiev, Y. Ney, A. Kharma, S. Griffin, M. I. Masood, C. Jacob, The  Small Matter of a Red Ox, a Particularly Sensitive Pink Cat, and the  Quest for the Yellow Stone of Wisdom. Curr. Pharmacol. Rep.  4:380–396 (2018)

[25]      K. Khairan, J. Vincent, C. Jacob, Study Cytotoxicity of Haarlem Oil by Crystal Violet Staining Assay. Res. J. Chem. Environ. 22, 198-202, (2018)

[26]      S. Shaaban, D. Vervandier-Fasseur,P.  Andreoletti, A. Zarrouk, P. Richard, A. Negm, G. Manolikakes, ,C. Jacob,  M. Cherkaoui-Malki, Cytoprotective and antioxidant properties of  organic selenides for the myelin-forming cells, oligodendrocytes. Bioorg. Chem.80, 43-56 (2018)

[27]      Y. Ney, M. J. Nasim, A. Kharma, L. A. Youssef, C. Jacob,  Small Molecule Catalysts with Therapeutic Potential Molecules; 23(4), 765 (2018)  

[28]      R. Leontiev, N. Hohaus, C. Jacob, M. C.  H. Gruhlke,  A. J. Slusarenko, A Comparison of the Antibacterial and  Antifungal Activities of Thiosulfinate Analogues of Allicin. Scientific Reports; 8, 6763 (2018)

[29]      S. Griffin, M. Sarfraz, S. F. Hartmann,  S. R. Pinnapireddy, M. J. Nasim, U. Bakowsky, M. C. M. Keck, C. Jacob,  Resuspendable Powders of Lyophilized Chalcogen Particles with Activity  against Microorganisms. Antioxidants;7(2), 23. (2018)

[30]      M. Sarfraz, S. Griffin, T. G. Sad, R.  Alhasan, M. J. Nasim, M. I. Masood, K. H. Schäfer, C. E.C.C. Ejike, C.  M. Keck ,C. Jacob, A. P. Ebokaiwe,  Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Into antimicrobial Materials. Antioxidants; 7(4), 60 (2018) 

[31]      S. Griffin, M. Sarfraz, V. Farida, M: J.  Nasim, A. P. Ebokaiwe,C. M. Keck, C. Jacob,  No time to waste organic  waste: Nanosizing converts remains of food processing into refined  materials, J Environ Manage, 210, 114-121 (2018)

[32]      G. A .M. Jardim, E. H. G. da Cruz, W. O.  Valença, D. J. B. Lima, B. C. Cavalcanti, C. Pessoa, J. Rafique, A. L.  Braga, C. Jacob, E. N. da Silva Júnior.  Synthesis of Selenium-Quinone  Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H  Bond Activation and Click Reactions. Molecules. ;23(1). (2018)

[33]      S. Griffin, M. I. Masood , M. J. Nasim,  M. Sarfraz, A. P.  Ebokaiwe, K-H. Schäfer, C. M. Keck, C. Jacob, Natural  Nanoparticles: A Particular Matter Inspired by Nature. Antioxidants.;7(1). (2018) 

[34]      M. J. Nasim, W. Ali, ,E.  Dominguez-Álvarez, E. N. da Silva Júnior, R. S. Z. Saleem, C. Jacob.  Reactive Selenium Species: Redox Modulation, Antioxidant, Antimicrobial  and Anticancer Activities. In book:  Organoselenium Compounds in Biology  and Medicine: Synthesis, Biological and Therapeutic Treatments. Royal Society of Chemistry, 277-302  (2018)

[35]      N.K. Tittikpina, F. Nana, S. Fontanay,  S. Philippot, K. Batawila, K. Akpagana, G. Kirsch, P. Chaimbault, C.  Jacob, R.E. Duval, Antibacterial activity and cytotoxicity of Pterocarpus erinaceus Poir extracts, fractions and isolated compounds. J Ethnopharmacol.212, 200-207. (2018) 

2017

 

[36]      K. Witek, M. J. Nasim, M. Bischoff, R.  Gaupp, P. Arsenyan, J. Vasiljeva, M. A. Marć , A. Olejarz, G. Latacz, K.  Kieć-Kononowicz, J. Handzlik, C.  Jacob, Selenazolinium Salts as "Small  Molecule Catalysts" with High Potency against ESKAPE Bacterial  Pathogens. Molecules.;22(12) (2017)

[37]      E. Y. Efe A. Mazumder, J. Lee,  A.  Gaigneaux F. Radogna, M. J. Nasim, Christo Christov , Claus Jacob, K.  Kim, M. Dicato, P. Chaimbault, C. Cerella, M. Diederich. Tubulin-binding  anticancer polysulfides induce cell death via mitotic arrest and  autophagic interference in colorectal cancer. Cancer Letters, 410, 139-157 (2017).

[38]      N. Koko Tittikpina, F. Nana, S.  Fontanay, S. Philippot, K. Batawila, K. Akpagana, G. Kirsch, P.  Chaimbault, C. Jacob, R. Emmanuel Duval, Antibacterial activity and  cytotoxicity of Pterocarpus erinaceus Poir extracts, fractions and  isolated compounds, Journal of Ethnopharmacology, (2017).

[39]      N. K. Tittikpina, W. Atakpama, H.  Pereki, M. J. Nasim, W. Ali, S. Fontanay, F. Nana, C. E. C. C.  Ejike,  G. Kirsch, R. E. Duval, P. Chaimbault, S. D. Karou, K. Batawila, K.  Akpagana, C. Jacob ‘Capiture’ plants with interesting biological  activities: a case to go. Open chemistry, 15, 1-11 (2017).

[40]      E. Jabeen, N. K. Janjua,  S. Ahmed, E.  Domínguez-Álvarez, C. Jacob. A selective and sensitive monitoring of the  OH radical using flavonoid-modified electrodes. Electrochimica Acta,  258 (20) , 228-235 ( 2017).

[41]      F. Albrecht, R. Leontiev, C. Jacob, A.J. Slusarenko, An Optimized Facile Procedure to Synthesize and Purify Allicin, Molecules, 22, (2017).

[42]      E.C. Estevam, S. Griffin, M.J. Nasim, P.  Denezhkin, R. Schneider, R. Lilischkis, E. Dominguez-Alvarez, K. Witek,  G. Latacz, C. Keck, K.H. Schafer, K. Kie-Kononowicz, J. Handzlik, C.  Jacob, Natural selenium particles from Staphylococcus carnosus: Hazards  or particles with particular promise?, Journal of Hazardous Materials, 324,  22-30, (2017).

[43]      W.O. Valenca, T.V. Baiju, F.G. Brito,  M.H. Araujo, C. Pessoa, B.C. Cavalcanti, C.A. de Simone, C. Jacob,  I.N.N. Namboothiri, E.N. da Silva, Synthesis of Quinone-Based  N-Sulfonyl-1,2,3-triazoles: Chemical Reactivity of Rh(II) Azavinyl  Carbenes and Antitumor Activity, Chemistry select, 2 4301-4308, (2017).

[44]      S. Griffin, R. Alkhayer, S. Mirzoyan, A.  Turabyan, P. Zucca, M. Sarfraz, M. J. Nasim, A. Trchounian, A.  Rescigno, C. M. Keck, C. Jacob, Nanosizing Cynomorium: Thumbs up for  Potential Antifungal Applications. Inventions, 2(3), 24 1-10, (2017).

[45]      G.I. Giles, M.J. Nasim, W. Ali, C. Jacob, The Reactive Sulfur Species Concept: 15 Years On. Antioxidants, 6(2):38, 1-29, (2017).

[46]      J. Rendeková, D. Vlasáková, P. Arsenyan,  J. Vasiljeva, M. J. Nasim, K. Witek, E. Domínguez-Álvarez, E.  Żesławska, D. Mániková, W. Tejchman, R. S. Z. Saleem, K. Rory, J.  Handzlik, M. Chovanec, The Selenium-Nitrogen Bond as Basis for Reactive  Selenium Species with Pronounced Antimicrobial Activity, Current Organic Synthesis, 14, (2017).

[47]      M. Grman, M. J. Nasim, R. Leontiev, A.  Misak, V. Jakusova, K. Ondrias, C. Jacob, Inorganic Reactive  Sulfur-Nitrogen Species: Intricate Release Mechanisms or Cacophony in  Yellow, Blue and Red?, Antioxidants, 6(1), (2017).

[48]      L. Faulstich, S. Griffin, M.J. Nasim,  M.I. Masood, W. Ali, S. Alhamound, Y. Omran, H. Kim, A. Kharma, K.H.  Schaefer, R. Lilischkis, M. Montenarh, C. Keck, C. Jacob, Nature's  Hat-trick: Can we use sulfur springs as ecological source for materials  with agricultural and medical applications?, International . Biodeterioration and  Biodegradation, 119, 678-686, (2017).

[49]      C. Zwergel, B. Czepukojc, E. Evain-Bana,  Z. Xu, G. Stazi, M. Mori,  A. Patsilinakos, A. Mai, B. Botta, R. Ragno,  D. Bagrel, G. Kirsch , P. Meiser, C. Jacob,  M. Montenarh,   S. Valente, Novel coumarin- and quinolinone-based polycycles as cell  division cycle 25-A and -C phosphatases inhibitors induce proliferation  arrest and apoptosis in cancer cells, European Journal of  Medicinal. Chemistry, 134, 316-333,  ( 2017).

2016

 

[50]      S. Griffin, N. K. Tittikpina, A.  Al-marby, R. Alkhayer, P. Denezhkin, K. Witek K. A. Gbogbo, K. Batawila,  R. E. Duval, M. J. Nasim, N. A. Awadh-Ali, G. Kirsch, P. Chaimbault,  K-H. Schäfer, C. M. Keck, J. Handzlik, C. Jacob,  Turning Waste into  Value: Nanosized Natural Plant Materials of Solanum incanum L. and  Pterocarpus erinaceus Poir with Promising Antimicrobial Activities, Pharmaceutics, 8(2): 11, (2016).

[51]      E. C. Estevam, L. Faulstich, S. Griffin,  T. Burkholz, C. Jacob. Polysulfides in Biology: From Intricate  Chemistry to an Astonishing Yet Hidden Biological Activity.  Current Organic Chemistry, 20(2) : 211 – 217, (2016).

[52]      E. Domínguez-Álvarez, M. Gajdács, G.  Spengler, J.A. Palop, M.A. Marć,  K. Kieć-Kononowicz,  L. Amaral, J.  Molnár, C. Jacob, J. Handzlik, C. Sanmartín, Identification of  selenocompounds with promising properties to reverse cancer multidrug  resistance, Bioorganic and Medicinal Chemistry Letters 26(12):2821-4, (2016).

[53]      O. Talhi, L. Brodziak-Jarosz, J.  Panning, B. Orlikova, C. Zwergel, T. Tzanova, S. Philippot, D.C. G. A.  Pinto, F. A. A. Paz, C. Gerhäuser, T. P. Dick, C. Jacob, M. Diederich,  D. Bagrel, G. Kirsch, A. M. S. Silva, One-Pot Synthesis of  Benzopyran-4-ones with Cancer Preventive and Therapeutic Potential. European Journal of  Organic Chemistry, 5, 965–975, (2016).

[54]      A. Al-Marby, C.E.C.C. Ejike, M.J. Nasim,  N.A. Awadh-Ali, R.A. Al-badani, G.M.A. Alghamdi , C. Jacob, Nematicidal  and antimicrobial activities of methanol extracts of 17 plants, of  importance in ethnopharmacology, obtained from the Arabian Peninsula, Journal of  Intercultural  Ethnopharmacology, 5(1): 1-6, (2016).

[55]      N.K. Tittikpina, C.E.C.C. Ejike, E.  Castelluci Estevam, M.J. Nasim, S. Griffin, P. Chaimbault, G. Kirsch, W.  Atakpama, K. Batawila, C. Jacob, Togo to go: Products and compounds  derived from local plants for the treatment of diseases endemic in  sub-Saharan Africa, African Journal of Traditional Complementary and  Alternative Medicine, 13(1):85-94, (2016).

2015

 

[56]      E. Castellucci Estevam, S. Griffin, M.J.  Nasim, D. Zieliński, J. Aszyk, M. Osowicka, N. Dawidowska, R. Idroes,  A. Bartoszek, C. Jacob, Inspired by Nature: The Use of Plant-derived  Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ, Natural Product Communication, 10(10), 1733-1738, (2015).

[57]      D. Rezk Allah, L. Schwind, I. Abu Asali,  J. Nasim, C. Jacob, C. Götz, M. Montenarh, A scent of therapy:  Synthetic polysulfanes with improved physico-chemical properties induce  apoptosis in human cancer cells, International  Journal of  Oncology, 47 (3), 991-1000, (2015).

[58]      C. Zwergel, S. Valente, C. Jacob, A. Mai, Emerging approaches for histone deacetylase inhibitor drug discovery, Expert Opinion on Drug Discovery, 10 (6), (2015).

[59]      M. Grman, E. Ondriasova, J. Nasim, C. Jacob, K. Ondrias, Decomposition of S-nitrosoglutathione by interaction with organic polysulfides and reduced thiols, Nitric Oxide, 47, (2015).

[60]      E. Castellucci Estevam , K. Witek , L.  Faulstich , M.J. Nasim , G. Latacz  , E. Domínguez-Álvarez  , K.  Kieć-Kononowicz , M. Demasi , J. Handzlik, C. Jacob, Aspects of a  Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living  Cells with Possible Implications for Drug Design, Molecules, 20, 13894-13912, (2015).

[61]      A.K.K. Bhasin, C. Jacob, F. Sasse, K.  Karaghiosoff , K.K. Bhasin, S.K. Mehta, Alka Sharma, Rishu, Design,  synthesis and characterization of picoline based organoselenium  compounds, 1,2-bis(pyridine-2/3/4-yl)methyl diselanes: X-ray crystal  structure of 1,2-bis(pyridine-3-y1) methyldiselane, Journal of Organometallic Chemistry, 785, 19-25, (2015).

2014

 [62]      E. Domínguez, D. Plano, M. Font, A.  Calvo, C. Prior, C. Jacob, J.A. Palop, C. Sanmartín, Synthesis and  antiproliferative activity of novel selenoester derivative, European Journal of Medicinal Chemistry, 73, 153-166 (2014).

[63]      O. Talhi, M. Schnekenburger, J. Panning,  D.G.C. Pinto, J.A. Fernandes, F.A. Almeida Paz, C. Jacob, M. Diederich,  A.M.S. Silva, Bis(4-hydroxy-2H-chromen-2-one): Synthesis and effects on  leukemic cell lines proliferation and NF-jB regulation, Bioorganic & Medicinal Chemistry, 22, 3008–3015 (2014)

[64]      A. Nucci, F.M. Merlo, M. De Nisco, S.  Pedatella, F. Rossi, C. Jacob, R. Caputo, A. Mastino,  Se-(2-aminoalkyl)selenocysteines as biochemical redox agents. A tool to  contrast cell injury induced by aflatoxin B1 in HepG2 cells, Amino Acids, 46(2), 459-470 (2014).

[65]      B. Czepukojc, A.K. Baltes, M. Kelkel, C.  Cerella, U.M. Viswanathan, F. Salm, T. Burkholz, C. Schneider, M.  Montenarh, M. Diederich, C. Jacob, Towards pharmaceutically useful,  redox-modulating polysulfanes based on naturally occurring garlic  compounds, Food and Chemical Toxicology, 64, 249–257 (2014).

[66]      P. Du, U.M. Viswanathan, K. Khairan, T.  Buric, N.E.B. Saidu, Z. Xu, B. Hanf, I. Bazukyan, A. Trchounian, F.  Hannemann, I. Bernhardt, T. Burkholz, B. Diesel, A.K. Kiemer, K.-H.  Schaefer, M. Montenarh, G. Kirsch, C. Jacob, Synthesis of amphiphilic,  chalcogen-based redox modulators with in vitro cytotoxic activity  against cancer cells, macrophages and microbes, Med.Chem.Comm., 5, 25-31 (2014).

[67]      P. Du, U.M. Viswanathan, Z. Xu, H.  Ebrahimnejad, B. Hanf, T. Burkholz, M. Schneider, I. Bernhardt, G.  Kirsch, M. Montenarh, C. Jacob, Synthesis and biological activity of  amphiphilic seleninic acid derivatives with considerable activity  against membranes, cancer cells and certain pathogenic microbes, Journal of Hazardous Materials, 269, 74–82 (2014).

[68]      P. Du, N.E:B. Saidu, J. Intemann, C.  Jacob, M. Montenarh, A new tellurium-containing amphiphilic molecule  induces apoptosis in HCT116 colon cancer cells, Biochim Biophys Acta, 1840(6), 1808-16 (2014).

[69]      T. Burkholz, M. Egert, C. Jacob,  Elektrochemische Dekontamination von leitenden Oberflächen: Von  grundlegenden Ideen zu neuen Ansätzen, WOMAG Oberflächen, Ausgabe 6/2014.

[70]      O. Talhi, M. Schnekenburger, J. Panning,  D.G.C. Pinto, J.A. Fernandes, F.A. Almeida Paz, C. Jacob, M. Diederich,  A.M.S. Silva, Bis(4-hydroxy-2H-chromen-2-one): Synthesis and effects on  leukemic cell lines proliferation and NF-κB regulation, Bioorganic & Medicinal Chemistry, 22 (11), 3008–3015 (2014).

[71]      V. Jamier, W. Marut, S. Valente, C.  Chéreau, S. Chouzenoux, C. Nicco, H. Lemaréchal, B. Weill, G. Kirsch, C.  Jacob, F. Batteux, Chalcone-Coumarin Derivatives as Potential  Anti-Cancer Drugs: An in vitro and in vivo Investigation, Anti-Cancer Agents in Medicinal Chemistry, 14(7), 963-74 (2014).

[72]      D. Mániková, L.M. Letavayová, D.  Vlasáková, P. Košík, E. Castellucci Estevam, M.J. Nasim, M. Gruhlke, A.  Slusarenko, T. Burkholz, C. Jacob, M. Chovanec, Intracellular  Diagnostics: Hunting for the Mode of Action of Redox-Modulating Selenium  Compounds in Selected Model Systems, Molecules, 19(8), 12258-12279 (2014).

[73]      C. Jacob, Special Issue: Redox Active Natural Products and Their Interaction with Cellular Signalling Pathways, Molecules, 19, 19588-19593 (2014).

[74]      L.-O. Klotz, X. Hou, C. Jacob, 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling, Molecules, 19, 14902-14918 (2014).

[75]      S. Shaaban, F. Sasse, T. Burkholz, C.  Jacob, Sulfur, selenium and tellurium pseudopeptides: Synthesis and  biological evaluation, Bioorganic & Medicinal Chemistry, 22, 3610–3619 (2014).

[76]      C. Jacob, G. Kirsch, A. Slusarenko, P.G.  Winyard, T. Burkholz (eds.), Recent Advances in Redox Active Plant and  Microbial Products: From basic chemistry to widespread applications in  Medicine and Agriculture, Springer Science, ISBN: 978-9401789523 (2015).

[77]      T. Burkholz, C. Jacob, A word on redox  activity, in: C. Jacob, G. Kirsch, A. Slusarenko, P.G. Winyard, T.  Burkholz (eds.), Recent Advances in Redox Active Plant and Microbial  Products: From basic chemistry to widespread applications in Medicine  and Agriculture, Springer Science (2015).

[78]      H. Ebrahimnejad, T. Burkholz, C. Jacob,  Treasures along the oligomeric road from flavonoids to polyphenols and  tannins, in: C. Jacob, G. Kirsch, A. Slusarenko, P.G. Winyard, T.  Burkholz (eds.), Recent Advances in Redox Active Plant and Microbial  Products: From basic chemistry to widespread applications in Medicine  and Agriculture, Springer Science (2015).

[79]      L.S. Sargsyan, K.R. Grigoryan, T.  Burkholz, S.A. Markarian, C. Jacob, Fluorescence characterisation of  human haemoglobin binding binding with tannic acid, Chemical Journal of  Armenia, 67(2-3), 181-187 (2014).

[80]      C. Jacob, L. Faulstich, M.J Nasim, T.  Burkholz, Von der Natur inspiriert: Redox-aktive Nahrungsbestandteile  (Metabolite) mit vielseitigen Anwendungen in der Medizin und  Landwirtschaft, Magazin Forschung, Ausgabe 2/2014 (2014)

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